14325-05-4 Usage
Uses
Used in Pharmaceutical Applications:
TIN PROTOPORPHYRIN IX DICHLORIDE is used as a selective inhibitor for [Heme Oxygenase-1 (HO-1)] for [preventing hyperbilirubinemia in neonates and studying the role of HO-1 activity in cells and animals].
Used in Research Applications:
TIN PROTOPORPHYRIN IX DICHLORIDE is used as a research tool for [studying the role of HO-1 activity] for [understanding the effects of HO-1 inhibition on various cellular processes and its potential therapeutic applications].
Used in Medical Applications:
TIN PROTOPORPHYRIN IX DICHLORIDE is used as a therapeutic agent for [preventing hyperbilirubinemia] for [blocking the increased HO-1 activity postnatally in neonates and reducing the risk of associated health complications].
Check Digit Verification of cas no
The CAS Registry Mumber 14325-05-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,4,3,2 and 5 respectively; the second part has 2 digits, 0 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 14325-05:
(7*1)+(6*4)+(5*3)+(4*2)+(3*5)+(2*0)+(1*5)=74
74 % 10 = 4
So 14325-05-4 is a valid CAS Registry Number.
InChI:InChI=1/C34H32N4O4.Sn/c1-7-21-17(3)25-13-26-19(5)23(9-11-33(39)40)31(37-26)16-32-24(10-12-34(41)42)20(6)28(38-32)15-30-22(8-2)18(4)27(36-30)14-29(21)35-25;/h7-8,13-16H,1-2,9-12H2,3-6H3,(H,39,40)(H,41,42);/q-4;+4/b25-13-,26-13-,27-14-,28-15-,29-14-,30-15-,31-16-,32-16-;
14325-05-4Relevant academic research and scientific papers
METHODS FOR SYNTHESIZING METAL MESOPORPHYRINS
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Page/Page column 6, (2012/10/08)
Embodiments describe methods of synthesizing metal mesoporphyrin compounds. In embodiments, a metal mesoporphyrin compound may be formed by hemin transmetallation and subsequent hydrogenation of the tin protoporphyrin IX to form a metal mesoporphyrin. In other embodiments, a method of synthesizing a metal mesoporphyrin compound comprises forming a protoporphyrin methyl ester from hemin and converting the protoporphyrin methyl ester intermediate to a metal mesoporphyrin compound through metal insertion and hydrogenation. In other embodiments, a metal mesoporphyrin compound may be formed from hemin by a hydrogen-free hydrogenation method to form a mesoporphyrin IX intermediate followed by metal insertion and hydrogenation. In embodiments, a method of synthesizing a metal mesoporphyrin compound comprises forming a mesoporphyrin IX dihydrochloride intermediate compound and converting the mesoporphyrin IX intermediate to a metal mesoporphyrin compound through metal insertion. In embodiments, a metal mesoporphyrin compound may be formed directly from hemin without isolation of any intermediates.
