14328-77-9Relevant articles and documents
Synthesis and structure-activity relationship of a novel series of heterocyclic sulfonamide γ-secretase inhibitors
Pu, Jun,Kreft, Anthony F.,Aschmies, Suzan H.,Atchison, Kevin P.,Berkowitz, Joshua,Caggiano, Thomas J.,Chlenov, Micheal,Diamantidis, George,Harrison, Boyd L.,Hu, Yun,Huryn, Donna,Steven Jacobsen,Jin, Mei,Lipinski, Kerri,Lu, Peimin,Martone, Robert L.,Morris, Koi,Sonnenberg-Reines, June,Riddell, Dave R.,Sabalski, Joan,Sun, Shaiu-Ching,Wagner, Erik,Wang, Yiqun,Xu, Zheng,Zhou, Hua,Resnick, Lynn
experimental part, p. 4708 - 4717 (2009/10/23)
γ-Secretase inhibitors have been shown to reduce the production of β-amyloid, a component of the plaques that are found in brains of patients with Alzheimer's disease. A novel series of heterocyclic sulfonamide γ-secretase inhibitors that reduce β-amyloid levels in cells is reported. Several examples of compounds within this series demonstrate a higher propensity to inhibit the processing of amyloid precursor protein compared to Notch, an alternative γ-secretase substrate.
