1433045-22-7Relevant academic research and scientific papers
Synthesis, chemical properties, and biological evaluations of some twin-drug type C2-symmetrical derivatives
Fujisaki, Fumiko,Usami, Haruka,Nakashima, Saya,Nishida, Sho,Fujioka, Toshihiro,Kashige, Nobuhiro,Miake, Fumio,Sumoto, Kunihiro
, p. 665 - 675 (2013)
We describe the synthesis and chemical properties of newly designed C 2-symmetrical twin-drug type aminoguanidines or 4- aminomethyloxazolidinone derivatives (4-7) in which a long chain alkyl group [-(CH2)10-] was used as a linker. Synthesis of some triplet-drug type symmetrical oxazolidinones (8) is also described. Among the tested compounds, the aminoguanidine derivative 4a showed the highest α-glucosidase inhibition activity (IC50 = 76.3 μmol/L).
