143306-65-4

Basic information

• Product Name: 1-PIPERIDINECARBOXYLIC ACID, 4-HYDROXY-3,3-DIMETHYL-, 1,1-DIMETHYLETHYL ESTER
• Synonyms: 1-PIPERIDINECARBOXYLIC ACID, 4-HYDROXY-3,3-DIMETHYL-, 1,1-DIMETHYLETHYL ESTER;tert-butyl 4-hydroxy-3,3-diMethylpiperidine-1-carboxylate;4-hydroxy-3,3-diMethyl-1-piperidinecarboxylic acid tert-butyl ester;1-Boc-4-hydroxy-3,3-diMethylpiperidine;4-Hydroxy-3,3-diMethyl-1-piperidinecarboxylic Acid 1,1-DiMethylethyl Ester
• CAS NO: 143306-65-4
• Molecular Formula: C₁₂H₂₃NO₃
• Molecular Weight: 229.318
• Mol File: 143306-65-4.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 306.3±35.0 °C(Predicted)
• Appearance: /
• Density: 1.041±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 14.85±0.40(Predicted)
• CAS DataBase Reference: 1-PIPERIDINECARBOXYLIC ACID, 4-HYDROXY-3,3-DIMETHYL-, 1,1-DIMETHYLETHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 1-PIPERIDINECARBOXYLIC ACID, 4-HYDROXY-3,3-DIMETHYL-, 1,1-DIMETHYLETHYL ESTER(143306-65-4)
• EPA Substance Registry System: 1-PIPERIDINECARBOXYLIC ACID, 4-HYDROXY-3,3-DIMETHYL-, 1,1-DIMETHYLETHYL ESTER(143306-65-4)

Safety Data

• RIDADR: UN2811
• Hazardous Substances Data: 143306-65-4(Hazardous Substances Data)

Usage

Uses

4-Hydroxy-3,3-dimethyl-1-piperidinecarboxylic Acid 1,1-Dimethylethyl Ester is a useful synthetic intermediate. It can be used to prepare hydroxyquinoxalinecarboxamides for treatment of blood coagulation disorders.

Upstream product

• 324769-06-4 tert-butyl 3,3-dimethyl-4-oxopiperidine-1-carboxylate 

Downstream Products

• 1233228-02-8 3,3-dimethyl-4-(4-nitro-phenoxy)-piperidine-1-carboxylic acid tert-butyl ester 

Relevant articles and documents

DUAL NAV1.2/5HT2A INHIBITORS FOR TREATING CNS DISORDERS

Compounds of formula I: I are disclosed, as are pharmaceutical compositions containing such compounds. Methods of treating neurological or psychiatric disorders in a patient in need are also disclosed. Such disorders include depression, bipolar disorder, pain, schizophrenia, obsessive compulsive disorder, addiction, social disorder, attention deficit hyperactivity disorder, an anxiety disorder, autism, a cognitive impairment, or a neuropsychiatric symptom such as apathy, depression, anxiety, psychosis, aggression, agitation, impulse control disorders, and sleep disorders in neurological disorders such as Alzheimer's and Parkinson's diseases.

SUBSTITUTED BENZAMIDES AND METHODS OF USE THEREOF

The invention provides compounds having the general formula I, and pharmaceutically acceptable salts thereof, wherein the variables RA, RAA, subscript n, ring A, X2, L, subscript m, X1, R1, R2, R3, R4, R5, and RN have the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compositions.

HYDROXYQUINOXALINECARBOXAMIDE DERIVATIVE

The present invention provides a novel hydroxyquinoxaline carboxamide derivative that is useful for preventing and/or treating blood coagulation disorders. A compound represented by formula (i), or a pharmacologically acceptable salt thereof: wherein, each of R1 and R2 independently represents a group such as a hydrogen atom or a halogen atom; R3 represents a group such as a hydrogen atom; each of R4 and R5 independently represents a group such as a hydrogen atom, a halogen atom or a C1-4 alkyl group; each of R6 and R7 independently represents a hydrogen atom or a C1-4 alkyl group; X represents a group such as a C3-10 cycloalkyl group, C6-10 aryl group or a 5- to 10-membered heterocyclic group, which may be substituted with substituent(s) selected from substituent group α; Y represents a group such as -CO-, -O- or -NRa-, and Ra represents a group such as a hydrogen atom or a C1-4 alkyl group.