14333-90-5Relevant academic research and scientific papers
1-phenyl-2-phenylaminoethyl ketone derivative and medical application
-
Paragraph 0125; 0126, (2020/04/17)
The invention belongs to the field of pharmaceutical chemicals, and relates to a micromolecular inhibitor of polymyxin drug-resistant protein MCR-1 and application thereof. The invention relates to acompound shown as a formula I, a pharmaceutically accept
Design, synthesis and biological evaluation of 1-Phenyl-2-(phenylamino) Ethanone Derivatives as Novel MCR-1 Inhibitors
Lan, Xiu-juan,Yan, Hai-tao,Lin, Feng,Hou, Shi,Li, Chen-chen,Wang, Guang-shu,Sun, Wei,Xiao, Jun-hai,Li, Song
supporting information, (2019/08/07)
Polymyxins are considered to be the last-line antibiotics that are used to treat infections caused by multidrug-resistant (MDR) gram-negative bacteria; however, the plasmid-mediated transferable colistin resistance gene (mcr-1) has rendered polymyxins ine
The Synthesis of 3-Aryl-6-alkylpyridazines
Liang, Jason
, p. 1297 - 1299 (2007/10/02)
Nine compounds of general structure R-X-Y-R' where X is a para-disubstituted phenyl ring and Y is a 3,6-disubstituted-pyridazine ring were synthesized.These can be used as liquid crystal dopents.A general procedure for their synthesis was developed.N-Alkyl benzene and ethyl butyrylacetate were used as starting materials.The purification of reaction intermediates was not necessary if preparative hplc was used to purify the final products.Very pure materials were obtained with good yield.Their structure was confirmed by carbon 13 nmr.
