143340-74-3 Usage
Molecular structure
A complex molecule with a fused heterocyclic ring system and a side chain containing a four-carbon linker with a substituted phenoxy group.
Heterocyclic ring
The presence of both carbon and nitrogen atoms in the ring structure.
Side chain
Contains a four-carbon linker and a substituted phenoxy group.
Potential applications
Pharmaceutical, agrochemical, and materials science industries.
Unique structure
The compound's structure contributes to its potential for biological activity.
Biological activity
Ability to interact with biological systems, which may lead to potential therapeutic effects or applications.
Synthesis
The process of creating the compound through chemical reactions and the formation of chemical bonds.
Properties
Characteristics of the compound, such as solubility, stability, and reactivity, which may influence its potential applications.
Research and development
The compound is an interesting target for further research in drug discovery and materials chemistry due to its unique structure and potential applications.
Drug discovery
The process of identifying and developing new pharmaceutical compounds for therapeutic use.
Materials chemistry
The study and development of new materials with unique properties for various applications, such as electronics, energy storage, and construction.
Check Digit Verification of cas no
The CAS Registry Mumber 143340-74-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,3,3,4 and 0 respectively; the second part has 2 digits, 7 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 143340-74:
(8*1)+(7*4)+(6*3)+(5*3)+(4*4)+(3*0)+(2*7)+(1*4)=103
103 % 10 = 3
So 143340-74-3 is a valid CAS Registry Number.
143340-74-3Relevant academic research and scientific papers
Folate-Synthesizing Enzyme System as Target for Development of Inhibitors and Inhibitor Combinations against Candida albicans - Synthesis and Biological Activity of New 2,4-Diaminopyrimidines and 4′-Substituted 4-Aminodiphenyl Sulfones
Otzen, Thomas,Wempe, Ellen G.,Kunz, Brigitte,Bartels, Rainer,Lehwark-Yvetot, Gudrun,H?nsel, Wolfram,Schaper, Klaus-Jürgen,Seydel, Joachim K.
, p. 240 - 253 (2007/10/03)
The paper describes the design, synthesis, and testing of inhibitors of folate-synthesizing enzymes and of whole cell cultures of Candida albicans. The target enzymes used were dihydropteroic acid synthase (SYN) and dihydrofolate reductase (DHFR). Several series of new 2,4-diaminopyrimidines were synthesized and tested as inhibitors of DHFR and compared with their activity against DHFR derived from mycobacteria and Escherichia coli. To test for selectivity, also rat DHFR was used. A series of substituted 4-aminodiphenyl sulfones was tested for inhibitory activity against SYN and the I50 values compared to those obtained previously against Plasmodium berghei- and E. coll-derived SYN. Surprisingly, QSAR equations show very similar structural dependencies. To find an explanation for the large difference in the I50 values observed for enzyme inhibition (SYN, DHFR) and for inhibition of cell cultures of Candida, mutant strains with overexpressed efflux pumps and strains in which such pumps are deleted were included in the study and the MICs compared. Efflux pumps were responsible for the low activity of some of the tested derivatives, others showed no increase in activity after pumps were knocked out. In this case it may be speculated that these derivatives are not able to enter the cells.
