143347-22-2Relevant academic research and scientific papers
Aliphatic propargylamines as specific MAO-B inhibitors
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, (2008/06/13)
A component having the following formula I: STR1 wherein X represents an integer ranging from 1 to 2 or 7 to 13; Y represents an integer ranging from 0 to 5; Z represents an integer ranging from 0 to 5; R1, R2 and R3 are the same or different and represent H or a straight chain or branched lower alkyl; and R' and R" are the same or different and represent H or halogen, and pharmaceutically acceptable salts thereof. Preferably, the lower alkyl has between 1 and 4 carbon atoms and the halogen is selected from the group consisting of fluorine, chlorine, bromine and iodine. The compound is useful as a MAO-B inhibitor. Also within the scope of the present invention is a composition for the inhibition of MAO-B activity and a method for alleviating Parkinsonism, Alzheimer's disease, depression, attention deficit hyperactive disorders, aging and other neuropsychiatric disorders and for improving the quality of life. They comprise the use of a compound of Formula I wherein x is an integer ranging from 1 to 13.
