143353-30-4

Basic information

• Product Name: (3aS,4R,7R,9R,10R,11R,13R,15R,15aR)-4-ethyl-11-methoxy-3a,7,9,11,13,15-hexamethyl-2,6,8,14-tetraoxo-1-(4-phenylbutyl)tetradecahydro-2H-oxacyclotetradecino[4,3-d][1,3]oxazol-10-yl 3,4,6-trideoxy-3-(dimethylamino)-beta-D-xylo-hexopyranoside
• CAS NO: 143353-30-4
• Molecular Formula: C₄₁H₆₄N₂O₁₀
• Molecular Weight: 744.9543
• Mol File: 143353-30-4.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 862.5°C at 760 mmHg
• Flash Point: 475.4°C
• Density: 1.17g/cm³
• Vapor Pressure: 1.01E-31mmHg at 25°C
• Refractive Index: 1.545
• CAS DataBase Reference: (3aS,4R,7R,9R,10R,11R,13R,15R,15aR)-4-ethyl-11-methoxy-3a,7,9,11,13,15-hexamethyl-2,6,8,14-tetraoxo-1-(4-phenylbutyl)tetradecahydro-2H-oxacyclotetradecino[4,3-d][1,3]oxazol-10-yl 3,4,6-trideoxy-3-(dimethylamino)-beta-D-xylo-hexopyranoside(CAS DataBase Reference)
• NIST Chemistry Reference: (3aS,4R,7R,9R,10R,11R,13R,15R,15aR)-4-ethyl-11-methoxy-3a,7,9,11,13,15-hexamethyl-2,6,8,14-tetraoxo-1-(4-phenylbutyl)tetradecahydro-2H-oxacyclotetradecino[4,3-d][1,3]oxazol-10-yl 3,4,6-trideoxy-3-(dimethylamino)-beta-D-xylo-hexopyranoside(143353-30-4)
• EPA Substance Registry System: (3aS,4R,7R,9R,10R,11R,13R,15R,15aR)-4-ethyl-11-methoxy-3a,7,9,11,13,15-hexamethyl-2,6,8,14-tetraoxo-1-(4-phenylbutyl)tetradecahydro-2H-oxacyclotetradecino[4,3-d][1,3]oxazol-10-yl 3,4,6-trideoxy-3-(dimethylamino)-beta-D-xylo-hexopyranoside(143353-30-4)

Safety Data

• Hazardous Substances Data: 143353-30-4(Hazardous Substances Data)

Usage

General Description

The chemical "(3aS,4R,7R,9R,10R,11R,13R,15R,15aR)-4-ethyl-11-methoxy-3a,7,9,11,13,15-hexamethyl-2,6,8,14-tetraoxo-1-(4-phenylbutyl)tetradecahydro-2H-oxacyclotetradecino[4,3-d][1,3]oxazol-10-yl 3,4,6-trideoxy-3-(dimethylamino)-beta-D-xylo-hexopyranoside" is a complex organic compound with a long, branching structure. It has a molecular formula of C48H78N2O13 and a molecular weight of 897.16 g/mol. The chemical features a combination of oxo, methoxy, and phenyl groups, as well as a tetraoxo-oxacyclotetradecino ring system and a trideoxy-xylo-hexopyranoside moiety. The presence of an ethyl and dimethylamino side chain adds to its complex structure. Due to its intricate and specific arrangement of atoms and functional groups, this compound likely possesses unique chemical and biological properties, making it of interest for further study in various fields, including medicine and biochemistry.

Upstream product

• 160145-83-5 2'-O-acetyl-10,11-didehydro-11-deoxy-12-O-(1H-1-imidazoylcarbonyl)-3-O-descladinosyl-3-oxo-6-O-methyl-erythromycin A 
• 160145-81-3 Acetic acid (2S,3R,4S,6R)-4-dimethylamino-2-((3R,5R,6R,7R,9R,11R,12R,13R,14R)-14-ethyl-13-hydroxy-12-methanesulfonyloxy-7-methoxy-3,5,7,9,11,13-hexamethyl-2,4,10-trioxo-oxacyclotetradec-6-yloxy)-6-methyl-tetrahydro-pyran-3-yl ester 
• 214694-76-5 2'-O-acetyl-10,11-didehydro-11-deoxy-3-O-descladinosyl-3-oxo-6-O-methyl-erythromycin A 
• 143353-81-5 3-Ode-[(2,6-dideoxy-3-methyl-3-O-methyl-α-L-ribohexopyranosyl)oxy]-6-O-methylerythromycin 2￠-acetate 
• 118058-74-5 3-O-descladinosylclarithromycin 
• 81103-11-9 clarithromycin 
• 13214-66-9 4-phenyl-1-butylamine 
• 143353-82-6 Acetic acid (2S,3R,4S,6R)-4-dimethylamino-2-((3R,5R,6R,7R,9R,11R,12R,13S,14R)-14-ethyl-12,13-dihydroxy-7-methoxy-3,5,7,9,11,13-hexamethyl-2,4,10-trioxo-oxacyclotetradec-6-yloxy)-6-methyl-tetrahydro-pyran-3-yl ester 

Relevant articles and documents

Synthesis and antibacterial activity of ketolides (6-O-methyl-3- oxoerythromycin derivatives): A new class of antibacterials highly potent against macrolide-resistant and -susceptible respiratory pathogens

In the search for new antibiotics active against macrolide-resistant pneumococci and Haemophilus influenzae, we synthesized a new class of 3-oxo- 6-O-methylerythromycin derivatives, so-called 'ketolides'. A keto function was introduced in position 3 after removal of L-cladinose, a sugar which has long been thought essential. Further modifications of the macrolactone backbone allowed us to obtain three different series of 9-oxime, 11,12- carbamate, and 11,12-hydrazonocarbamate ketolides. These compounds were found to be very active against penicillin/erythromycin-resistant pneumococci and noninducers of MLS(B) resistance. The 11,-12-substituted ketolide 61 (HMR 3004) demonstrated a potent activity against multiresistant pneumococci associated with a well-balanced activity against all bacteria involved in respiratory infections including H. influenzae, Mycoplasma catarrhalis, group A streptococci, and atypical bacteria. In addition HMR 3004 displayed high therapeutic activity in animals infected by all major strains, irrespective of their resistance phenotype.