143357-91-9Relevant academic research and scientific papers
Sodium halides as the source of electrophilic halogens in green synthesis of 3-halo- and 3,n-dihalobenzo[b]thiophenes
Kesharwani, Tanay,Kornman, Cory,Tonnaer, Amanda,Hayes, Amanda,Kim, Seoyoung,Dahal, Nikesh,Romero, Ralf,Royappa, Andrew
, p. 2973 - 2984 (2018/05/23)
A convenient methodology for the synthesis of mono- and di-halogenated benzo[b]thiophenes is described herein, which utilizes copper(II) sulfate pentahydrate and various sodium halides in the presence of substituted 2-alkynylthioanisoles. The proposed met
STUDY OF THE RACTION OF SEVERAL KETONE ENOLATES WITH 3-IODOBENZOTHIOPHENE UNDER THERMALLY INITIATED SRN1 REACTION CONDITIONS
Prats, Montserrat,Galvez, Carmen,Beltran, Lluis
, p. 1039 - 1046 (2007/10/02)
The reaction of 3-iodobenzothiophene (1) with the potassium enolates of cyclohexanone (2a), acetone (2b), and acetophenone (2c) in DMSO for 1 h at room temperature in the dark, gave the desired α-hetaryl ketones (3a-c) in low yield.The thermally activated SRN1 reaction with the ion enolate (2a) was studied in more detail and it was found that the radical chain SRN1 mechanism could compete with one of ionic character.
