1433608-82-2

Upstream product

• 1313379-34-8 (S,E)-2-amino-7-(4-fluoro-2-(pyridin-3-yl)phenyl)-4-methyl-7,8-dihydro-6H-quinazolin-5-one oxime 
• 254454-54-1 tert-butyl-3-iodoazetidine-1-carboxylate 
• 1433605-21-0 (E)-2-amino-7-(4-fluoro-2-(pyridin-3-yl)phenyl)-4-methyl-7,8-dihydro-6H-quinazolin-5-one oxime 
• 1433605-37-8 (S,E)-2-amino-7-(4-fluoro-2-(pyridin-3-yl)phenyl)-4-methyl-7,8-dihydro-6H-quinazolin-5-one O-acetyl oxime 

Downstream Products

• 1433609-09-6 (S)-2-amino-7-(4-fluoro-2-(pyridin-3-yl)phenyl)-4-methyl-7,8-dihydro-6H-quinazolin-5-one O-((1-acetyl)azetidin-3-yl)oxime 
• 1433608-87-7 (S,E)-2-amino-7-(4-fluoro-2-(pyridin-3-yl)phenyl)-4-methyl-7,8-dihydro-6H-quinazolin-5-one O-(azetidin-3-yl)oxime 
• 1433608-77-5 (S)-2-amino-7-(4-fluoro-(2-pyridin-3-yl)phenyl)-4-methyl-7,8-dihydro-6H-quinazolin-5 one-O-(1-methylazetidin-3-yl)oxime 

Relevant academic research and scientific papers

QUINAZOLINE DERIVATIVES WITH HSP90 INHIBITORY ACTIVITY

Compounds of general formula (I): or a stereoisomer, tautomer, polymorph, hydrate, solvate, or a pharmaceutically acceptable salt thereof, wherein R is as defined herein, are useful for the treatment of diseases and conditions which are mediated by excessive or inappropriate Hsp90 activity such as proliferative diseases, e.g. cancers, viral and fungal infections, neurodegenerative or inflammatory diseases or conditions. The invention also relates to the preparation of these compounds as well as to pharmaceutical compositions comprising them.