143361-87-9Relevant articles and documents
Novel cycloalkylthiophene-imine derivatives bearing benzothiazole scaffold: Synthesis, characterization and antiviral activity evaluation
Ke, Shaoyong,Wei, Yanhong,Yang, Ziwen,Wang, Kaimei,Liang, Ying,Shi, Liqiao
supporting information, p. 5131 - 5134 (2013/09/12)
A series of novel cycloalkylthiophene-imine derivatives containing benzothiazole unit were designed, synthesized and evaluated for their anti-viral activities. The bio-evaluation results indicated that some of the target compounds (such as 5g, 5i, 5u) exhibited good to moderate antiviral effect on CVB5, ADV7 and EV71 viruses, however, these compounds did not have inhibition activity against H1N1 virus. Especially, the compounds 4c and 4d also exhibited high antiviral activities, which provide a new and efficient approach to evolve novel multi-functional antiviral agents by rational integration of active pharmacophores.
Synthesis of 3-Hetaryl-4,5,6,7-tetrahydrobenzothiophenes
Sabnis, R. W.,Rangnekar, D. W.
, p. 1027 - 1029 (2007/10/02)
A novel efficient synthesis of 3-hetaryl-4,5,6,7-tetrahydrobenzothiophenes was achieved by the cyclocondensation of ethyl 2-amino-4,5,6,7-tetrahydrobenzothiophene-3-carboxylate with selected o-substituted aromatic amines or with alifatic, aromatic a