1433716-89-2Relevant academic research and scientific papers
Pyrazolylamine Derivatives Reveal the Conformational Switching between Type i and Type II Binding Modes of Anaplastic Lymphoma Kinase (ALK)
Tu, Chih-Hsiang,Lin, Wen-Hsing,Peng, Yi-Hui,Hsu, Tsu,Wu, Jian-Sung,Chang, Chun-Yu,Lu, Cheng-Tai,Lyu, Ping-Chiang,Shih, Chuan,Jiaang, Weir-Torn,Wu, Su-Ying
, p. 3906 - 3919 (2016/05/24)
Most anaplastic lymphoma kinase (ALK) inhibitors adopt a type I binding mode, but only limited type II ALK structural studies are available. Herein, we present the structure of ALK in complex with N1-(3-4-[([5-(tert-butyl)-3-isoxazolyl]aminocarbonyl)amino
