143376-73-2Relevant articles and documents
Synthesis and biological evaluation of substituted 3-(2′-benzimidazolyl)coumarin platinum(II) complexes as new telomerase inhibitors
Meng, Ting,Qin, Qi-Pin,Wang, Zhen-Rui,Peng, Li-Ting,Zou, Hua-Hong,Gan, Zhen-Yuan,Tan, Ming-Xiong,Wang, Kai,Liang, Fu-Pei
, p. 143 - 150 (2018)
Eight new platinum(II) complexes Pt1–Pt8 with substituted 3?(2′?benzimidazolyl) coumarins were successfully synthesized and characterized by single crystal X-ray diffraction analysis, nuclear magnetic resonance spectroscopy (NMR), electrospray ionization-mass spectrometry (ESI-MS), infrared spectrophotometry (IR) and elemental analysis. Crystallographic data of these Pt1–Pt8 complexes showed that the Pt(II) has distorted four-coordinated square planar geometry. Pt1–Pt8 were found to display high cytotoxic activity in vitro against the cisplatin-resistant SK-OV-3/DDP cancer cells with a low IC50 from 1.01–10.32 μM, but low cytotoxicity on the normal HL-7702 cells. Further studies revealed that Pt1–Pt3 induced apoptosis in SK-OV-3/DDP cancer cells via mitochondria dysfunction signaling pathways. Our findings also indicated that Pt1 was a telomerase inhibitor targeting c-myc promoter elements.