143376-73-2

Basic information

• Product Name: 3-(1H-benzimidazol-2-yl)-6,8-dibromo-2H-chromen-2-one
• Synonyms: 3-(1H-benzimidazol-2-yl)-6,8-dibromo-2H-chromen-2-one
• CAS NO: 143376-73-2
• Molecular Formula: C16H8Br2N2O2
• Molecular Weight: 420.05492
• Mol File: 143376-73-2.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3-(1H-benzimidazol-2-yl)-6,8-dibromo-2H-chromen-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(1H-benzimidazol-2-yl)-6,8-dibromo-2H-chromen-2-one(143376-73-2)
• EPA Substance Registry System: 3-(1H-benzimidazol-2-yl)-6,8-dibromo-2H-chromen-2-one(143376-73-2)

Safety Data

• Hazardous Substances Data: 143376-73-2(Hazardous Substances Data)

Upstream product

• 90-59-5 3,5-Dibromosalicylaldehyde 
• 4414-88-4 1H-benzimidazol-2-acetonitrile 

Relevant articles and documents

Synthesis and biological evaluation of substituted 3-(2′-benzimidazolyl)coumarin platinum(II) complexes as new telomerase inhibitors

Eight new platinum(II) complexes Pt1–Pt8 with substituted 3?(2′?benzimidazolyl) coumarins were successfully synthesized and characterized by single crystal X-ray diffraction analysis, nuclear magnetic resonance spectroscopy (NMR), electrospray ionization-mass spectrometry (ESI-MS), infrared spectrophotometry (IR) and elemental analysis. Crystallographic data of these Pt1–Pt8 complexes showed that the Pt(II) has distorted four-coordinated square planar geometry. Pt1–Pt8 were found to display high cytotoxic activity in vitro against the cisplatin-resistant SK-OV-3/DDP cancer cells with a low IC50 from 1.01–10.32 μM, but low cytotoxicity on the normal HL-7702 cells. Further studies revealed that Pt1–Pt3 induced apoptosis in SK-OV-3/DDP cancer cells via mitochondria dysfunction signaling pathways. Our findings also indicated that Pt1 was a telomerase inhibitor targeting c-myc promoter elements.