143390-24-3Relevant academic research and scientific papers
The design, synthesis, and structure-activity relationships of a series of macrocyclic MMP inhibitors
Steinman, Douglas H.,Curtin, Michael L.,Garland, Robert B.,Davidsen, Steven K.,Heyman, H. Robin,Holms, James H.,Albert, Daniel H.,Magoc, Terry J.,Nagy, Ildiko B.,Marcotte, Patrick A.,Li, Junling,Morgan, Douglas W.,Hutchins, Charles,Summers, James B.
, p. 2087 - 2092 (2007/10/03)
A series of succinate-derived hydroxamic acids incorporating a macrocyclic ring were designed, synthesized, and evaluated as inhibitors of matrix metalloproteinases. The inhibitors were designed based on the published X-ray crystal structure of batimastat (1) complexed with human neutrophil collagenase (MMP-8). The synthesized compounds were shown to inhibit selected MMPs in vitro with low nanomolar potency.
N-SULPHONYLAMINO DERIVATIVES OF DIPEPTIDE COMPOUNDS AS METALLOPROTEINASE INHIBITORS
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, (2008/06/13)
Compounds of formula (1) are described wherein R represents a--CONHOH, carboxyl, carboxyl ester, or--P(O)(X 1 R 8)X 2 R. sup.9, where X 1 and X 2 are the same or different and each is oxygen or sulphur, R 8 and R 9 are the same or different and each repre
