143391-86-0Relevant academic research and scientific papers
Biosynthetic Studies on the Chitinase Inhibitor, Allosamidin. Origin of the Carbon and Nitrogen Atoms.
Zhou, Ze-Yang,Sakuda, Shohei,Yamada, Yasuhiro
, p. 1649 - 1652 (2007/10/02)
Allosamidin 1 is a potent insect chitinase inhibitor produced by Streptomyces sp.The biosynthesis of compound 1 was studied by feeding experiments with labelled precursors.Incorporation experiments using - and D-glucose as well as doubly labelled D-glucosamine revealed that each skeleton of N-acetyl-D-allosamine and allosamizoline 2 was derived grom D-glucosamine.Further experiments with L-arginine and -methionine clarified the origin of the dimethylaminooxazoline moiety of compound 2.
