143392-18-1

Basic information

• Product Name: 2(5H)-Furanone, 3-(4-methylphenyl)-
• CAS NO: 143392-18-1
• Molecular Formula: C11H10O2
• Molecular Weight: 174.199
• Mol File: 143392-18-1.mol

Chemical Properties

• CAS DataBase Reference: 2(5H)-Furanone, 3-(4-methylphenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2(5H)-Furanone, 3-(4-methylphenyl)-(143392-18-1)
• EPA Substance Registry System: 2(5H)-Furanone, 3-(4-methylphenyl)-(143392-18-1)

Safety Data

• Hazardous Substances Data: 143392-18-1(Hazardous Substances Data)

Upstream product

• 50-00-0 formaldehyd 
• 66616-85-1 α-(4-methylphenyl)acrylic acid 
• 624-31-7 4-tolyl iodide 
• 201230-82-2 carbon monoxide 
• 766-97-2 4-n-methylphenylacetylene 
• 129313-32-2 (3-p-Tolyl-oxiranyl)-methanol 
• 74-88-4 methyl iodide 

Relevant articles and documents

Synthesis method of butene lactone compound

The invention discloses a synthesis method of a butene lactone compound, which comprises the following steps: adding an acrylic acid compound, paraformaldehyde, pentamethyl cyclopentadienyl carbonyl cobalt diiodide, AgSbF6 and sodium acetate into an organic solvent, heating under an air condition to react, and after the reaction is completed, performing post-treatment to obtain the butene lactone compound. According to the method, the butene lactone compound is synthesized from simple and easily available raw materials through a one-pot method, the conversion efficiency is high, and the step economy is good; meanwhile, the synthesis method is simple to operate, high in reaction yield and wide in substrate universality.

Cobalt-Catalyzed Vinylic C-H Addition to Formaldehyde: Synthesis of Butenolides from Acrylic Acids and HCHO

A carboxyl-assisted C-H functionalization of acrylic acids with formaldehyde to give butenolides is described. It is the first time that the addition of an inert vinylic C-H bond to formaldehyde has been achieved via cobalt-catalyzed C-H activation. The unique reactivity of the cobalt species was observed when compared with related Rh or Ir catalysts. γ-Hydroxymethylated butenolides were produced by the treatment of Na2CO3 after the catalytic reaction in one pot.

Butenolide synthesis from functionalized cyclopropenones

A general method to synthesize substituted butenolides from hydroxymethylcyclopropenones is reported. Functionalized cyclopropenones undergo ring-opening reactions with catalytic amounts of phosphine, forming reactive ketene ylides. These intermediates can be trapped by pendant hydroxy groups to afford target butenolide scaffolds. The reaction proceeds efficiently in diverse solvents and with low catalyst loadings. Importantly, the cyclization is tolerant of a broad range of functional groups, yielding a variety of α- and γ-substituted butenolides.

Reductive Carbonylation of Acetylenes under Water-Gas Shift Reaction Conditions. Synthesis of Furan-2(5H)-ones from Terminal and Non-substituted Acetylenes

Under water-gas reaction conditions terminal and non-substituted acetylenes are selectively converted into furan-2(5H)-ones by catalysis with a rhodium carbonyl cluster.