143394-93-8

Basic information

• Product Name: (R)-3-Aminodihydrofuran-2,5-dione hydrochloride
• Synonyms: (R)-3-Aminodihydrofuran-2,5-dione hydrochloride;(R)-3-AMINODIHYDROFURAN-2,5-DIONE HCL;(3R)-3-Aminotetrahydrofuran-2,5-dione hydrochloride;2,5-Furandione, 3-aminodihydro-, hydrochloride, (R)- (9CI)
• CAS NO: 143394-93-8
• Molecular Formula: C4H6ClNO3
• Molecular Weight: 151.5483
• Mol File: 143394-93-8.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 312.4 °C at 760 mmHg
• Flash Point: 142.7 °C
• Appearance: /
• Vapor Pressure: 0.000392mmHg at 25°C
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: (R)-3-Aminodihydrofuran-2,5-dione hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-3-Aminodihydrofuran-2,5-dione hydrochloride(143394-93-8)
• EPA Substance Registry System: (R)-3-Aminodihydrofuran-2,5-dione hydrochloride(143394-93-8)

Safety Data

• Hazardous Substances Data: 143394-93-8(Hazardous Substances Data)

Usage

General Description

(R)-3-Aminodihydrofuran-2,5-dione hydrochloride is a chemical compound that belongs to the class of organic compounds known as imidazoles. It is used in research and experimental procedures as a reagent and intermediate. (R)-3-Aminodihydrofuran-2,5-dione hydrochloride has the potential to exhibit a variety of biological activities, including antiviral, antineoplastic, and antifungal properties. It is also being studied for its potential applications in the development of new drugs and pharmaceuticals. Additionally, (R)-3-Aminodihydrofuran-2,5-dione hydrochloride may have uses in the synthesis of other organic compounds and materials.

InChI:InChI=1/C4H5NO3.ClH/c5-2-1-3(6)8-4(2)7;/h2H,1,5H2;1H/t2-;/m1./s1

Upstream product

• 56-84-8 L-Aspartic acid 
• 7719-12-2 phosphorus trichloride 

Downstream Products

• 17812-32-7 H-Asp-OMe 

Relevant articles and documents

Amino Acid Anhydride Hydrochlorides as Acylating Agents in Friedel-Crafts Reaction: A Practical Synthesis of L-Homophenylalanine

The use of amino acid hydrochlorides as acylating agents in Friedel-Crafts reaction is presented for the first time. A practical and convenient route to L-homophenylalanine from L-aspartic acid in 3 steps in 80 percent overall yield with >99 percent ee is thus achieved.

A polypeptide material aspartic acid tert-butyl β - α - methyl ester hydrochloride preparation method

The invention discloses a polypeptide material aspartic acid tert-butyl β - α - methyl ester hydrochloride of the preparation method, is mainly composed of complex technology, cycle is long, the yield is low, the cost is high, the risk is high, does not meet the technical problems of production and the like. Preparation method of this invention comprises the following steps: 1st step, the aspartic acid suspended in dry tetrahydrofuran, in phosphorus oxychloride under the action of the aspartic acid in the preparation into the anhydride hydrochloride; 2nd step, aspartic acid anhydride hydrochloride suspended in methanol reaction to obtain the aspartic acid α - methyl ester hydrochloride, triethylamine for adjusting pH value so that the aspartic acid methyl α - separated out; 3rd step, aspartic acid methyl α - suspended in methylene chloride, access isobutene, concentrated sulfuric, sealed reaction to obtain the oil of aspartic acid tert-butyl methyl α - β -; 4th step, the oil of aspartic acid tert-butyl methyl α - β - dissolved in ethyl ether, dropping ethyl ether - hydrochloric acid gas, the final product is obtained α - β - tert-butyl aspartic acid methyl ester hydrochloride.

Process for isolation of aspartyl dipeptide esters

The isolation of certain dipeptide esters, known to be potent sweetening agents, is achieved by selectively extracting, with a suitable alkanol in a heterogeneous system, an aqueous solution containing the dipeptide ester together with a variety of impurities.