1433962-81-2Relevant academic research and scientific papers
Organocatalytic asymmetric Michael addition of ethyl nitroacetate to enones using natural amino acids-derived C1-symmetric chiral primary-secondary diamines
Zhou, Yirong,Liu, Qiang,Gong, Yuefa
, p. 3011 - 3014 (2013)
A highly organocatalytic asymmetric Michael addition of ethyl nitroacetate to enones by using C1-symmetric chiral primary-secondary diamines has been developed. In assistance of o-nitrobenzoic acid, chiral amine 1f which was derived from l-tryptophane and d-camphor can effectively promote the transformation in high yields (up to 96%) and enantioselectivities (up to 95%) under mild conditions.
A polystyrene-supported 9-amino(9-deoxy)epi quinine derivative for continuous flow asymmetric Michael reactions
Izquierdo, Javier,Ayats, Carles,Henseler, Andrea H.,Pericàs, Miquel A.
supporting information, p. 4204 - 4209 (2015/04/14)
A polystyrene (PS)-supported 9-amino(9-deoxy)epi quinine derivative catalyzes Michael reactions affording excellent levels of conversion and enantioselectivity using different nucleophiles and structurally diverse enones. The highly recyclable, immobilized catalyst has been used to implement a single-pass, continuous flow process (residence time: 40 min) that can be operated for 21 hours without significant decrease in conversion and with improved enantioselectivity with respect to batch operation. The flow process has also been used for the sequential preparation of a small library of enantioenriched Michael adducts.
