1433996-83-8

Basic information

• Product Name: Ald-Ph-PEG5-t-butyl ester
• Synonyms: Ald-Ph-PEG5-t-butyl ester;DF-PEG5-CH2CH2COOtBu
• CAS NO: 1433996-83-8
• Molecular Formula: C22H34O8
• Molecular Weight: 426.50056
• Mol File: 1433996-83-8.mol
• Article Data: 0

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Ald-Ph-PEG5-t-butyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Ald-Ph-PEG5-t-butyl ester(1433996-83-8)
• EPA Substance Registry System: Ald-Ph-PEG5-t-butyl ester(1433996-83-8)

Safety Data

• Hazardous Substances Data: 1433996-83-8(Hazardous Substances Data)

Usage

Description

Ald-Ph-PEG5-t-butyl ester is a polyethylene glycol (PEG) reagent featuring a benzaldehyde group that readily reacts with molecules containing aminooxy (NH2O) functional groups. This reagent also incorporates a t-butyl ester, which serves as an acid-labile protecting group. This unique structure allows for versatile applications in various industries, particularly in the field of chemical synthesis and drug development.

Uses

Used in Chemical Synthesis:
Ald-Ph-PEG5-t-butyl ester is used as a synthetic building block for the creation of complex molecules and polymers. The benzaldehyde group facilitates the formation of imine linkages with aminooxy-containing molecules, enabling the synthesis of novel chemical entities with potential applications in various fields.
Used in Drug Development:
In the pharmaceutical industry, Ald-Ph-PEG5-t-butyl ester is used as a conjugation agent for the development of targeted drug delivery systems. The reactive benzaldehyde group allows for the attachment of therapeutic molecules to PEG chains, improving their solubility, stability, and circulation time in the body. This can lead to enhanced efficacy and reduced side effects for various medications.
Used in Bioconjugation:
Ald-Ph-PEG5-t-butyl ester is employed as a bioconjugation reagent for the attachment of biologically active molecules, such as proteins, peptides, or nucleic acids, to PEG chains. This can improve the pharmacokinetic properties of these biomolecules, enhancing their stability, solubility, and half-life in biological systems.
Used in Material Science:
In the field of material science, Ald-Ph-PEG5-t-butyl ester is used as a component in the development of novel materials with tailored properties. The incorporation of PEG chains into polymer matrices can result in materials with improved biocompatibility, hydrophilicity, and tunable mechanical properties.
Used in Diagnostics:
Ald-Ph-PEG5-t-butyl ester can be utilized in the development of diagnostic tools, such as imaging agents or biosensors. The reactive benzaldehyde group allows for the attachment of signaling moieties or targeting ligands to PEG chains, enabling the creation of highly specific and sensitive diagnostic agents.