1434002-89-7Relevant academic research and scientific papers
A redox economical synthesis of bioactive 6,12-guaianolides
Wen, Bo,Hexum, Joseph K.,Widen, John C.,Harki, Daniel A.,Brummond, Kay M.
supporting information, p. 2644 - 2647 (2013/07/19)
Syntheses of two 6,12-guaianolide analogs are reported within. The scope of the tandem allylboration/lactonization chemistry is expanded to provide a functionalized allene-yne-containing α-methylene butyrolactone that undergoes a Rh(I)-catalyzed cyclocarbonylation reaction to afford a 5-7-5 ring system. The resulting cycloadducts bear a structural resemblance to other NF-κB inhibitors such as cumambrin A and indeed were shown to inhibit NF-κB signaling and cancer cell growth.
