1434004-06-4

Upstream product

• 1434003-91-4 ethyl 3-azido-4-ethynylbenzoate 
• 1260650-82-5 C₁₁H₁₁NO₂ 
• 1434003-95-8 methyl 5-[2-azido-4-(ethoxycarbonyl)phenyl]-3-isopropyl-2-(4-methoxybenzyl)-2,3-dihydro-1H-pyrazole-1-carboxylate 

Downstream Products

• 1434004-23-5 6-ethyl 1-methyl 4-benzyl-3-isopropyl-1,4-dihydropyrazolo[4,3-b]indole-1,6-dicarboxylate 
• 1434004-27-9 6-ethyl 1-methyl 4-benzyl-3-isopropyl-2-(4-methoxybenzyl)-1,2,3,4-tetrahydropyrazolo[4,3-b]-indole-1,6-dicarboxylate 

Relevant academic research and scientific papers

Diversity-oriented synthesis of pyrazolo[4,3-b]indoles by gold-catalysed three-component annulation: Application to the development of a new class of CK2 inhibitors

Pyrazolo[4,3-b]indole derivatives have been designed as novel CK2 inhibitor compounds based on the binding mode analysis of a previously reported phenylpyrazole-type CK2 inhibitor. A series of pyrazolo[4,3-b]indoles and related dihydropyrazolo[4,3-b]indoles were efficiently prepared from simple starting materials using a gold-catalysed three-component annulation reaction as a key step. Several of the newly synthesized compounds displayed high levels of inhibitory activity, indicating that the pyrazolo[4,3-b]indole core represents a promising scaffold for the development of potent CK2 inhibitors.