1434129-45-9Relevant academic research and scientific papers
From human immunodeficiency virus non-nucleoside reverse transcriptase inhibitors to potent and selective antitrypanosomal compounds
Venkatraj, Muthusamy,Arin, Kevin K.,Heeres, Jan,Joossens, Jurgen,Diri, Bertrand,Lyssens, Sophie,Michiels, Johan,Cos, Paul,Lewi, Paul J.,Vanham, Guido,Maes, Louis,Van Der Veken, Pieter,Augustyns, Koen
, p. 5241 - 5248 (2014/12/11)
The presence of a structural recognition motif for the nucleoside P2 transporter in a library of pyrimidine and triazine non-nucleoside HIV-1 reverse transcriptase inhibitors, prompted for the evaluation of antitrypanosomal activity. It was demonstrated that the structure-activity relationship for anti-HIV and antitrypanosomal activity was different. Optimization in the diaryl triazine series led to 6-(mesityloxy)-N2-phenyl-1,3,5-triazine-2,4-diamine (69), a compound with potent in vitro and moderate in vivo antitrypanosomal activity.
DISUBSTITUTED TRIAZINE DIMERS FOR TREATMENT AND/OR PREVENTION OF INFECTIOUS DISEASES
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Paragraph 0255; 0259; 0381; 0393; 0394, (2014/11/11)
The present invention relates to novel compounds (I) containing two disubstituted triazine rings covalently linked by an organic linker, thereby creating dimers. These compounds show activity against the causative infective agents of infectious diseases s
DISUBSTITUTED TRIAZINE DIMERS FOR TREATMENT AND/OR PREVENTION OF INFECTIOUS DISEASES
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Page/Page column 36; 53; 55, (2013/05/23)
The present invention relates to novel compounds (I) containing two disubstituted triazine rings covalently linked by an organic linker, thereby creating dimers. These compounds show activity against the causative infective agents of infectious diseases s
