143427-18-3Relevant academic research and scientific papers
Rhodium-Catalyzed C-H/C-H Cross Coupling of Benzylthioethers or Benzylamines with Thiophenes Enabled by Flexible Directing Groups
Yang, Shiping,Cheng, Rui,Zhao, Tingxing,Luo, Anping,Lan, Jingbo,You, Jingsong
supporting information, p. 5086 - 5090 (2019/07/03)
Reported herein is an efficient synthetic protocol to ortho-functionalized 2-aryl thiophenes via Rh(III)-catalyzed C-H/C-H cross coupling of benzylthioethers or benzylamines with thiophenes. Both ortho- and meta-substituted benzylthioethers give monoheteroarylated products, while ortho-unhindered substrates mainly provide diheteroarylated benzylthioethers. The C-H/C-H cross coupling of benzylamines with thiophenes exclusively generates diheteroarylated benzaldehydes. Mechanistic investigation discloses a three-step tandem process involving the ortho-C-H diheteroarylation of benzylamine, the oxidation of benzylamine to imine, and the hydrolysis of imine to aldehyde.
SYNTHESIS AND SPECTRAL STUDIES OF ALKYL-3- BENZOATES AND THEIR PHENYL SULFONYL DERIVATIVES
El-Bardan, Ali A.,Gohar, Gamal A.,El-Zahraa, Fatma,El-Hegazy, M.,Hamed, Ezzat A.
, p. 147 - 152 (2007/10/02)
New methyl and ethyl-3- benzoates and their corresponding phenyl sulfonyl derivatives have been synthesized and identified by UV, IR and 1H-NMR.Both phenylthio 1 and 2 as well as phenyl sulfonyl derivatives 3 and 4 showed a linear relationship between chemical shift δ ppm of the benzylic protons and ?-Hammett constants. Key words: Arylthio; aryl sulfonyl benzoates, 1H-NMR.
