1434289-65-2

Upstream product

• 7311-34-4 3,5-dimethoxybenzaldehdye 
• 85565-93-1 2-bromo-3,5-dimethoxy-benzaldehyde 
• 69405-32-9 methyl 2,2-Dimethoxypent-4-enoate 
• 224629-50-9 2-bromo-1,5-dimethoxy-3-vinylbenzene 
• 1434289-62-9 2,2-dimethoxypent-4-enal 

Relevant academic research and scientific papers

Syntheses of 3,4-benzotropolones by ring-closing metatheses

Ortho-lithiated styrenes or ortho-lithiated benzaldehyde dimethyl acetals were added to 2,2-dimethoxypent-4-enals 7. The resulting alcohols were carried on to the aromatic dienones 10. These were ring-closed by olefin metathesis. Hydrolysis of the dimethyl ketal moiety and enolization provided the 3,4-benzotropolones 5. Overall, this access comprises 4-6 steps and totaled a 22-81% yield.