1434289-75-4

Upstream product

• 1434289-62-9 2,2-dimethoxypent-4-enal 
• 59276-28-7 m-anisaldehyde dimethyl acetal 
• 69405-32-9 methyl 2,2-Dimethoxypent-4-enoate 
• 1434289-72-1 1-[2-(dimethoxymethyl)-6-methoxyphenyl]-2,2-dimethoxypent-4-en-1-ol 
• 591-31-1 3-methoxy-benzaldehyde 

Downstream Products

• 1434289-69-6 2,2-dimethoxy-1-(2-methoxy-6-vinylphenyl)pent-4-en-1-one 

Relevant academic research and scientific papers

Syntheses of 3,4-benzotropolones by ring-closing metatheses

Ortho-lithiated styrenes or ortho-lithiated benzaldehyde dimethyl acetals were added to 2,2-dimethoxypent-4-enals 7. The resulting alcohols were carried on to the aromatic dienones 10. These were ring-closed by olefin metathesis. Hydrolysis of the dimethyl ketal moiety and enolization provided the 3,4-benzotropolones 5. Overall, this access comprises 4-6 steps and totaled a 22-81% yield.