143440-14-6Relevant articles and documents
Development of Chiral Ureates as Chiral Strong Br?nsted Base Catalysts
Ishikawa, Sho,Kondoh, Azusa,Terada, Masahiro
, p. 3724 - 3728 (2020)
Recently, chiral Br?nsted bases having high basicity have emerged as a powerful tool in developing new catalytic enantioselective reactions. However, such chiral strong Br?nsted base catalysts are still very scarce. Herein, we report the development of a chiral anionic Br?nsted base having a N,N′-dialkyl ureate moiety as a basic site. Its prominent catalytic activity was demonstrated in the enantioselective addition reactions of α-thioacetamides as less acidic pronucleophiles with various electrophiles. Thus, the newly developed chiral catalyst with high accessibility and structural tunability would expand the scope of viable enantioselective transformations under Br?nsted base catalysis.
Chiral Thioureas Promote Enantioselective Pictet-Spengler Cyclization by Stabilizing Every Intermediate and Transition State in the Carboxylic Acid-Catalyzed Reaction
Klausen, Rebekka S.,Kennedy, C. Rose,Hyde, Alan M.,Jacobsen, Eric N.
supporting information, p. 12299 - 12309 (2017/09/12)
An investigation of the mechanism of benzoic acid/thiourea co-catalysis in the asymmetric Pictet-Spengler reaction is reported. Kinetic, computational, and structure-activity relationship studies provide evidence that rearomatization via deprotonation of
