143446-73-5 Usage
Uses
Used in Pharmaceutical Industry:
5-acetoxy-2-(R,S)butyryloxymethyl-1,3-oxathiolane was used as an appetite suppressant for the treatment of obesity due to its ability to inhibit the reuptake of key neurotransmitters, thereby inducing a feeling of fullness and reducing appetite. However, its use has been limited due to the potential cardiovascular risks associated with its consumption.
Used in Research and Development:
Although sibutramine has been withdrawn from the market, it may still be used in research and development settings to study the mechanisms of appetite suppression and weight loss, as well as to explore potential modifications or alternatives that could mitigate the cardiovascular risks while retaining the beneficial effects on appetite control.
Check Digit Verification of cas no
The CAS Registry Mumber 143446-73-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,3,4,4 and 6 respectively; the second part has 2 digits, 7 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 143446-73:
(8*1)+(7*4)+(6*3)+(5*4)+(4*4)+(3*6)+(2*7)+(1*3)=125
125 % 10 = 5
So 143446-73-5 is a valid CAS Registry Number.
InChI:InChI=1/C10H16O5S/c1-3-4-8(12)13-5-10-15-9(6-16-10)14-7(2)11/h9-10H,3-6H2,1-2H3
143446-73-5Relevant academic research and scientific papers
Facile preparation of α-acyloxyacetaldehyde, a versatile intermediate in the synthesis of antiviral nucleosides
Du, Jinfa,Watanabe, Kyoichi A.
, p. 1925 - 1930 (2007/10/03)
This report describes a novel and simple method for the preparation of a versatile intermediate, α-acyloxyacetaldehyde and its acetals, and its application to the synthesis of 4-acetoxy-2-acyloxymethyl-1,3-oxathiolane, an important intermediate in the syn
Preparation of intermediates useful in the synthesis of antiviral nucleosides
-
, (2008/06/13)
The present invention is an efficient process for the manufacture of α-acyloxyacetaldehyde, a key intermediate in the synthesis of 1,3-oxathiolane and 1,3-dioxolane nucleosides.
Method of manufacture of 1,3-oxathiolane nucleosides
-
, (2008/06/13)
Processes for the preparation of 1,3-oxathiolane nucleosides are provided that include efficient methods for the preparation of the 1,3-oxathiolane ring and subsequent condensation of the 1,3-oxathiolane with a pyrimidine or purine base. Using the processes described herein, the compounds can be provided as isolated enantiomers.
