1434620-82-2Relevant academic research and scientific papers
A novel lewis acid catalyzed [3 + 3]-annulation strategy for the syntheses of tetrahydro-β-carbolines and tetrahydroisoquinolines
Wang, Shaoyin,Chai, Zhuo,Zhou, Shuangliu,Wang, Shaowu,Zhu, Xiancui,Wei, Yun
supporting information, p. 2628 - 2631 (2013/07/19)
A novel Lewis acid catalyzed [3 + 3]-annulation process for the efficient syntheses of both tetrahydro-β-carbolines and tetrahydroisoquinolines from readily available benzylic alcohols and aziridines was developed, which would be a highly valuable complement to the widely used Pictet-Spengler reaction. A probable mechanism was proposed based on the isolation and characterization of two key intermediates. This strategy enables facile access to important alkaloid frameworks not easily available with other known methods.
