14348-21-1 Usage
General Description
4,9-Bis[(3-methyl-2-buten-1-yl)oxy]-7H-furo[3,2-g][1]benzopyran-7-one is a complex chemical compound with a long and intricate molecular structure. It is an organic compound that belongs to the class of furocoumarins, which are known to possess phototoxic and photoallergic properties. This particular chemical has multiple alkoxy groups attached to a furobenzopyran backbone, making it potentially useful in pharmaceutical and medicinal applications. However, it is important to handle and use this compound with caution due to its complex structure and potential phototoxicity. Additional research and testing may be necessary to fully understand its properties and potential uses.
Check Digit Verification of cas no
The CAS Registry Mumber 14348-21-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,4,3,4 and 8 respectively; the second part has 2 digits, 2 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 14348-21:
(7*1)+(6*4)+(5*3)+(4*4)+(3*8)+(2*2)+(1*1)=91
91 % 10 = 1
So 14348-21-1 is a valid CAS Registry Number.
14348-21-1Relevant articles and documents
Structure-activity relationships for naturally occurring coumarins as β-secretase inhibitor
Marumoto, Shinsuke,Miyazawa, Mitsuo
supporting information; experimental part, p. 784 - 788 (2012/03/22)
The present study was demonstrated to evaluate the effects of naturally occurring coumarins (NOCs) including simple coumarins, furanocoumarins, and pyranocoumarins on the inhibition of β-secretase (BACE1) activity. Of 41 NOCs examined, some furanocoumarins inhibited BACE1 activity, but simple coumarins and pyranocoumarins did not affect. The most potent inhibitor was 5-geranyloxy-8-methoxypsoralen (31), which has an IC50 value of 9.9 μM. Other furanocoumarin derivatives, for example, 8-geranyloxy-5- methoxypsoralen (35), 8-geranyloxypsoralen (24), and bergamottin (18) inhibited BACE1 activity, with the IC50 values 25.0 μM. Analyses of the inhibition mechanism by Dixon plots and Cornish-Bowden plots showed that compounds 18, 31 and 35 were mixed-type inhibitor. The kinetics of inhibition of BACE1 by coumarins 24 was non-competitive inhibitors.
