14348-21-1 Usage
Uses
Used in Pharmaceutical Industry:
4,9-Bis[(3-methyl-2-buten-1-yl)oxy]-7H-furo[3,2-g][1]benzopyran-7-one is used as a potential active pharmaceutical ingredient for its unique properties, which may contribute to the development of new medications. Its phototoxic and photoallergic characteristics could be harnessed for targeted therapies under controlled conditions.
Used in Medicinal Research:
In the field of medicinal research, 4,9-Bis[(3-methyl-2-buten-1-yl)oxy]-7H-furo[3,2-g][1]benzopyran-7-one serves as a subject for investigation to understand its interaction with biological systems. This could lead to insights into its therapeutic effects and potential side effects, guiding its safe and effective use in medicine.
Used in Chemical Synthesis:
4,9-Bis[(3-methyl-2-buten-1-yl)oxy]-7H-furo[3,2-g][1]benzopyran-7-one is utilized as a key intermediate in the synthesis of other complex organic compounds, particularly those with potential applications in various industries, including pharmaceuticals, agrochemicals, and materials science.
Check Digit Verification of cas no
The CAS Registry Mumber 14348-21-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,4,3,4 and 8 respectively; the second part has 2 digits, 2 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 14348-21:
(7*1)+(6*4)+(5*3)+(4*4)+(3*8)+(2*2)+(1*1)=91
91 % 10 = 1
So 14348-21-1 is a valid CAS Registry Number.
14348-21-1Relevant academic research and scientific papers
Structure-activity relationships for naturally occurring coumarins as β-secretase inhibitor
Marumoto, Shinsuke,Miyazawa, Mitsuo
supporting information; experimental part, p. 784 - 788 (2012/03/22)
The present study was demonstrated to evaluate the effects of naturally occurring coumarins (NOCs) including simple coumarins, furanocoumarins, and pyranocoumarins on the inhibition of β-secretase (BACE1) activity. Of 41 NOCs examined, some furanocoumarins inhibited BACE1 activity, but simple coumarins and pyranocoumarins did not affect. The most potent inhibitor was 5-geranyloxy-8-methoxypsoralen (31), which has an IC50 value of 9.9 μM. Other furanocoumarin derivatives, for example, 8-geranyloxy-5- methoxypsoralen (35), 8-geranyloxypsoralen (24), and bergamottin (18) inhibited BACE1 activity, with the IC50 values 25.0 μM. Analyses of the inhibition mechanism by Dixon plots and Cornish-Bowden plots showed that compounds 18, 31 and 35 were mixed-type inhibitor. The kinetics of inhibition of BACE1 by coumarins 24 was non-competitive inhibitors.
