1434817-05-6

Basic information

• Product Name: 4-(2,2,2-trifluoroethoxy)-2-trifluoromethylbenzenethiol
• Synonyms: 4-(2,2,2-trifluoroethoxy)-2-trifluoromethylbenzenethiol
• CAS NO: 1434817-05-6
• Molecular Weight: 276.202
• Mol File: 1434817-05-6.mol

Chemical Properties

• CAS DataBase Reference: 4-(2,2,2-trifluoroethoxy)-2-trifluoromethylbenzenethiol(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(2,2,2-trifluoroethoxy)-2-trifluoromethylbenzenethiol(1434817-05-6)
• EPA Substance Registry System: 4-(2,2,2-trifluoroethoxy)-2-trifluoromethylbenzenethiol(1434817-05-6)

Safety Data

• Hazardous Substances Data: 1434817-05-6(Hazardous Substances Data)

Upstream product

• 1434817-29-4 1-bromo-4-(2,2,2-trifluoro-ethoxy)-2-trifluoromethylbenzene 
• 1434817-23-8 4-(2,2,2-trifluoroethoxy)-2-trifluoromethyl-1-tritylsulfanylbenzene 
• 1208077-00-2 4-fluoro-2-(trifluoromethyl)benzenethiol 
• 40161-55-5 1-bromo-4-fluoro-2-(trifluoromethyl)benzene 
• 1434817-12-5 4-fluoro-2-trifluoromethyl-1-tritylsulfanyl benzene 
• 176225-09-5 2-(trifluoromethyl)-4-fluorobenzenesulfonyl chloride 

Downstream Products

• 1252637-07-2 (2S,4R)-1-(1-methylcyclopropanecarbonyl)-4-[4-(2,2,2-trifluoroethoxy)-2-trifluoromethylbenzenesulfonyl]pyrrolidine-2-carboxylic acid (1-cyanocyclopropyl)amide 
• 1434818-39-9 (2S,4R)-1-(1-methylcyclopropanecarbonyl)-4-[4-(2,2,2-trifluoroethoxy)-2-trifluoromethylphenylsulfanyl]pyrrolidine-2-carboxylic acid (1-cyanocyclopropyl)amide 

Relevant articles and documents

PROCESS FOR THE PREPARATION OF PROLINE DERIVATIVES

The present invention relates in part to a process for the preparation of a proline derivative of formula I wherein, R1 is C1-7-alkyl or wherein R4 is selected from the group consisting of C1-7-alkyl, halogen-C1-7-alkyl and phenyl optionally substituted by halogen; R2 is halogen or halogen-C1-7-alkyl; and R3 is selected from the group consisting of hydrogen, halogen, halogen-C1-7-alkyl, C1-7-alkoxy, halogen-C1-7-alkoxy and a 5- or 6-membered heterocyclic ring containing one or two nitrogen atoms, said ring being optionally substituted by C1-7-alkyl or halogen. The proline derivatives of the formula I are preferential inhibitors of the cysteine protease Cathepsin S and are therefore useful to treat metabolic diseases like diabetes, atherosclerosis, abdominal aortic aneurysm, peripheral arterial disease and diabetic nephropathy.

PROCESS FOR THE PREPARATION OF 1-ACYL-4-PHENYLSULFONYLPROLINAMIDE DERIVATIVES AND NEW INTERMEDIATES

A novel process for the preparation of proline derivatives of formula (I) wherein,R1 is selected from C1-7-alkyl or from formula (II) wherein R4 is selected from C1-7-alkyl, halogen-C1-7-alkyl or from phenyl which is optionally substituted by halogen; R2 is selected from halogen or halogen-C1-7-alkyl; and R3 is selected from hydrogen, halogen, halogen-C1-7-alkyl, C1-7-alkoxy, halogen-C1-7-alkoxy or from a 5- or 6-membered heterocyclic ring containing one or two nitrogen atoms, the ring which is optionally substituted by C1-7-alkyl or halogen is described. The proline derivatives of the formula I are preferential inhibitors of the cysteine protease Cathepsin S and are therefore useful to treat metabolic diseases like diabetes, atherosclerosis, abdominal aortic aneurysm, peripheral arterial disease and diabetic nephropathy.