143508-06-9

Upstream product

• 137238-61-0 O^ω-<5-<<<(4S,5R)-4-(cyclohexylmethyl)-3-<(1,1-dimethylethoxy)carbonyl>-2,2-dimethyl-5-oxazolidinyl>carbonyl>oxy>-5(R)-(4-morpholinomethyl)pentanoyl>-N^α-<(phenylmethoxy)carbonyl>-L-serine, 1,1-dimethylethyl ester 
• 137238-59-6 5-Hydroxy-6-morpholin-4-yl-hexanoic acid benzyl ester 
• 143614-69-1 (R)-5-Hydroxy-6-morpholin-4-yl-hexanoic acid benzyl ester 
• 137238-51-8 (3R,4S,7S,14R)-7-Amino-4-cyclohexylmethyl-3-hydroxy-14-morpholin-4-ylmethyl-1,9-dioxa-5-aza-cyclotetradecane-2,6,10-trione 
• 137238-62-1 (4S,5R)-4-Cyclohexylmethyl-2,2-dimethyl-oxazolidine-3,5-dicarboxylic acid 3-tert-butyl ester 5-((R)-4-carboxy-1-morpholin-4-ylmethyl-butyl) ester 
• 147505-11-1 (1R)-1-(4-morpholinomethyl)-5-oxo-5-(phenylmethoxy)pentyl (4S,5R)-4-(cyclohexylmethyl)-2,2-dimethyl-3-<(1,1-dimethylethoxy)carbonyl>-5-oxazolidinecarbxylate 
• 143614-44-2 (2R,9S,12S,13R)-12-(cyclohexylmethyl)-13-hydroxy-2-(4-morpholinomethyl)-9-<<(phenylmethoxy)carbonyl>amino>-6,10,14-trioxo-1,5-dioxa-11-azacyclotetradecane 
• 137226-54-1 (2R,9S,12S,13R)-12-(cyclohexylmethyl)-9--D-prolinyl>-L-phenylalanyl>-13-hydroxy-2-(4-morpholinomethyl)-6,10,14-trioxo-1,7-dioxa-11-azacyclotetradecane 
• 143508-36-5 (1R)-1-(4-morpholinomethyl)-5-oxo-5-(phenylmethoxy)pentyl (2R,3S)-4-cyclohexyl-2-hydroxy-3-<<(2S)-2-<<(1,1-dimethylethoxy)carbonyl>amino>-3-(phenylmethoxy)propanoyl>amino>butanoate 
• 137238-65-4 (R)-5-[(2R,3S)-3-((S)-2-tert-Butoxycarbonylamino-3-hydroxy-propionylamino)-4-cyclohexyl-2-hydroxy-butyryloxy]-6-morpholin-4-yl-hexanoic acid 
• 143616-04-0 (2R,9S,12S,13R)-12-(cyclohexylmethyl)-9-<<(1,1-dimethylethoxy)carbonyl>amino>-13-hydroxy-2-(4-morpholinomethyl)-6,10,14-trioxo-1,5-dioxa-11-azacyclotetradecane 
• 137238-88-1 4-Oxiranyl-butyric acid benzyl ester 

Relevant academic research and scientific papers

Highly Potent, Orally Active Diester Macrocyclic Human Renin Inhibitors

Replacing one amide bond in macrocyclic renin inhibitors of the general structure 1 and 2 with an ester linkage gave glutamate-derived inhibitors 3 and serine-derived inhibitors 4.While this oxygen-for-nitrogen exchange had little effect on potency in the