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14354-67-7

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  • Zincate(2-),[7,12-diethyl-3,8,13,17-tetramethyl-21H,23H-porphine-2,18-dipropanoato(4-)-kN21,kN22,kN23,kN24]-, dihydrogen, (SP-4-2)-(9CI)

    Cas No: 14354-67-7

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  • Zincate(2-),[7,12-diethyl-3,8,13,17-tetramethyl-21H,23H-porphine-2,18-dipropanoato(4-)-kN21,kN22,kN23,kN24]-, dihydrogen, (SP-4-2)-(9CI) cas 14354-67-7

    Cas No: 14354-67-7

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14354-67-7 Usage

Description

Zinc mesoporphyrin is a synthetic metalloporphyrin compound characterized by a central zinc ion surrounded by four pyrrole rings. It is known for its potential therapeutic properties, particularly as an inhibitor of heme oxygenase, an enzyme that plays a role in the breakdown of heme into biliverdin, carbon monoxide, and iron. Zinc mesoporphyrin's ability to mitigate the effects of conditions with excessive heme breakdown and subsequent iron overload, as well as its demonstrated protective effects against oxidative stress and inflammation-associated tissue damage, make it a promising candidate for further research and potential therapeutic applications.

Uses

Used in Pharmaceutical Applications:
Zinc mesoporphyrin is used as a therapeutic agent for conditions characterized by excessive heme breakdown and subsequent iron overload, such as hemolytic anemia and malaria. Its inhibitory effect on heme oxygenase helps mitigate the effects of these conditions.
Used in Oxidative Stress and Inflammation Management:
Zinc mesoporphyrin is used as a protective agent against oxidative stress and inflammation-associated tissue damage. Its preclinical studies have shown promise in this area, indicating its potential for further research and therapeutic applications in managing oxidative stress and inflammation-related conditions.
Used in Research and Development:
Zinc mesoporphyrin is used as a research compound for investigating its potential therapeutic properties and applications. Its role as a heme oxygenase inhibitor and its protective effects against oxidative stress and inflammation make it a valuable tool for exploring new treatment options for various diseases and conditions.

Check Digit Verification of cas no

The CAS Registry Mumber 14354-67-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,4,3,5 and 4 respectively; the second part has 2 digits, 6 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 14354-67:
(7*1)+(6*4)+(5*3)+(4*5)+(3*4)+(2*6)+(1*7)=97
97 % 10 = 7
So 14354-67-7 is a valid CAS Registry Number.
InChI:InChI=1/C34H36N4O4.Zn/c1-7-21-17(3)25-13-26-19(5)23(9-11-33(39)40)31(37-26)16-32-24(10-12-34(41)42)20(6)28(38-32)15-30-22(8-2)18(4)27(36-30)14-29(21)35-25;/h13-16H,7-12H2,1-6H3,(H,39,40)(H,41,42);/q-4;/b25-13-,26-13-,27-14-,28-15-,29-14-,30-15-,31-16-,32-16-;

14354-67-7Downstream Products

14354-67-7Related news

zinc mesoporphyrin (cas 14354-67-7) represses induced hepatic 5-aminolevulinic acid synthase and reduces heme oxygenase activity in a mouse model of acute hepatic porphyria08/04/2019

Zinc mesoporphyrin (ZnMP) is a potent inhibitor of heme oxygenase (HO) and represses 5-aminolevulinic acid synthase (ALAS). These properties make it a potential candidate for treatment of inducible acute hepatic porphyrias, diseases characterized by neurovisceral symptoms, and massive ALAS induc...detailed

zinc mesoporphyrin (cas 14354-67-7) induces rapid and marked degradation of the transcription factor bach1 and up-regulates HO-108/02/2019

Heme oxygenase 1 (HO-1) is the first and rate-controlling enzyme in heme degradation. Bach1 is a mammalian transcriptional repressor of HO-1. To understand how zinc mesoporphyrin (ZnMP) induces the expression of HO-1, we investigated the effects of ZnMP on Bach1 mRNA and protein levels in human ...detailed

14354-67-7Relevant articles and documents

Zinc(II) and copper(II) complexes with pheophytin and mesoporphyrin and their stability to UV-B irradiation: Vis spectroscopy studies

Zvezdanovic, Jelena B.,Markovic, Dejan Z.,Milenkovic, Sanja M.

, p. 187 - 199 (2012)

The stability of Zn(II) and Cu(II) complexes of porphyrin derivatives (pheophytin and mesoporphyrin) to UV-B irradiation was studied by absorbance spectroscopy in 95 % ethanol. The chosen porphyrins and their heavy metal complexes underwent first-order ph

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