14354-67-7 Usage
Description
Zinc mesoporphyrin is a synthetic metalloporphyrin compound characterized by a central zinc ion surrounded by four pyrrole rings. It is known for its potential therapeutic properties, particularly as an inhibitor of heme oxygenase, an enzyme that plays a role in the breakdown of heme into biliverdin, carbon monoxide, and iron. Zinc mesoporphyrin's ability to mitigate the effects of conditions with excessive heme breakdown and subsequent iron overload, as well as its demonstrated protective effects against oxidative stress and inflammation-associated tissue damage, make it a promising candidate for further research and potential therapeutic applications.
Uses
Used in Pharmaceutical Applications:
Zinc mesoporphyrin is used as a therapeutic agent for conditions characterized by excessive heme breakdown and subsequent iron overload, such as hemolytic anemia and malaria. Its inhibitory effect on heme oxygenase helps mitigate the effects of these conditions.
Used in Oxidative Stress and Inflammation Management:
Zinc mesoporphyrin is used as a protective agent against oxidative stress and inflammation-associated tissue damage. Its preclinical studies have shown promise in this area, indicating its potential for further research and therapeutic applications in managing oxidative stress and inflammation-related conditions.
Used in Research and Development:
Zinc mesoporphyrin is used as a research compound for investigating its potential therapeutic properties and applications. Its role as a heme oxygenase inhibitor and its protective effects against oxidative stress and inflammation make it a valuable tool for exploring new treatment options for various diseases and conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 14354-67-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,4,3,5 and 4 respectively; the second part has 2 digits, 6 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 14354-67:
(7*1)+(6*4)+(5*3)+(4*5)+(3*4)+(2*6)+(1*7)=97
97 % 10 = 7
So 14354-67-7 is a valid CAS Registry Number.
InChI:InChI=1/C34H36N4O4.Zn/c1-7-21-17(3)25-13-26-19(5)23(9-11-33(39)40)31(37-26)16-32-24(10-12-34(41)42)20(6)28(38-32)15-30-22(8-2)18(4)27(36-30)14-29(21)35-25;/h13-16H,7-12H2,1-6H3,(H,39,40)(H,41,42);/q-4;/b25-13-,26-13-,27-14-,28-15-,29-14-,30-15-,31-16-,32-16-;
14354-67-7Relevant articles and documents
Zinc(II) and copper(II) complexes with pheophytin and mesoporphyrin and their stability to UV-B irradiation: Vis spectroscopy studies
Zvezdanovic, Jelena B.,Markovic, Dejan Z.,Milenkovic, Sanja M.
, p. 187 - 199 (2012)
The stability of Zn(II) and Cu(II) complexes of porphyrin derivatives (pheophytin and mesoporphyrin) to UV-B irradiation was studied by absorbance spectroscopy in 95 % ethanol. The chosen porphyrins and their heavy metal complexes underwent first-order ph
