143540-88-9

Usage

Chemical Structure

A propanoic acid hydrazide with a naphthalene substituent

Usage

Building block for the synthesis of various organic compounds, reagent in organic chemical reactions, potential applications in pharmaceuticals and agrochemicals, biological activities for medicinal chemistry and drug development, precursor for other functionalized derivatives in chemical and pharmaceutical industries.

InChI:InChI=1/C13H14N2O2/c1-9(13(16)15-14)17-12-7-6-10-4-2-3-5-11(10)8-12/h2-9H,14H2,1H3,(H,15,16)

Upstream product

• 135-19-3 β-naphthol 
• 57416-30-5 2-(naphthalene-2-yloxy)propionic acid ethyl ester 

Downstream Products

• 1189163-60-7 1-(5-hydroxy-3,5-diphenyl-4,5-dihydropyrazol-1-yl)-2-(naphthalen-2-yloxy)propan-1-one 
• 507445-07-0 N-[1-(4-bromophenyl)ethylidene]-2-(naphthalen-2-yloxy)propionic acid hydrazide 
• 352447-05-3 N-(4-nitrobenzylidene)-2-(naphthalen-2-yloxy)propionic acid hydrazide 
• 100549-46-0 1-[2-(naphthalen-2-yloxy)propionyl]-4-phenyl thiosemicarbazide 

Relevant academic research and scientific papers

Synthesis and biological activity of triazolothiadiazines bearing naphthyloxyethyl moiety

A new series of [1,2,4] triazolo [3,4-b] [1,3,4] thiadiazines 5 incorporating α or β naphthyloxyethyl moiety were synthesized by an intramolecular ring transformation of (1,3,4-oxadiazole-2-yl) thio ketones 6 with hydrazine hydrate. The novel compounds we

Design, synthesis and hypolipidemic activity of novel 2-(naphthalen-2-yloxy)propionic acid derivatives as desmethyl fibrate analogs

A series of 2-(naphthalen-2-yloxy)propionic acid derivatives were prepared. The hypolipidemic activity of the new compounds as well as the intermediate acid 2 was evaluated in the high cholesterol diet (HCD) fed hyperlipidemic rat model. Interestingly, the S-alkylated mercaptotriazole 8b and the 1,3,4-oxadiazole 9 produced striking reduction of serum levels of total cholesterol (TC), triglycerides (TGs) and low-density lipoproteins (LDLs) and elevation of serum high-density lipoproteins (HDLs) being more active than the reference gemfibrozil. In addition, the 1,2,4-triazole 7a, the hydroxypyrazoline 10 and the pyrazolone derivative 11 exhibited good hypolipidemic activity on different lipid parameters.