143543-81-1

Basic information

• Product Name: (4,5-DIHYDRO-THIAZOL-2-YL)-[2-(4-METHOXY-PHENYL)-ETHYL]-AMINE
• Synonyms: (4,5-Dihydro-thiazol-2-yl)-[2-(4-methoxy-phenyl)-ethyl]-amine; 2-thiazolamine, 4,5-dihydro-N-[2-(4-methoxyphenyl)ethyl]-; N-[2-(4-Methoxyphenyl)ethyl]-4,5-dihydro-1,3-thiazol-2-amine
• CAS NO: 143543-81-1
• Molecular Formula: C₁₂H₁₆N₂OS
• Molecular Weight: 236.33
• Mol File: 143543-81-1.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 389.3°Cat760mmHg
• Flash Point: 189.3°C
• Appearance: /
• Density: 1.19g/cm³
• Vapor Pressure: 2.87E-06mmHg at 25°C
• Refractive Index: 1.6
• PKA: 7.36±0.10(Predicted)
• CAS DataBase Reference: (4,5-DIHYDRO-THIAZOL-2-YL)-[2-(4-METHOXY-PHENYL)-ETHYL]-AMINE(CAS DataBase Reference)
• NIST Chemistry Reference: (4,5-DIHYDRO-THIAZOL-2-YL)-[2-(4-METHOXY-PHENYL)-ETHYL]-AMINE(143543-81-1)
• EPA Substance Registry System: (4,5-DIHYDRO-THIAZOL-2-YL)-[2-(4-METHOXY-PHENYL)-ETHYL]-AMINE(143543-81-1)

Safety Data

• Hazardous Substances Data: 143543-81-1(Hazardous Substances Data)

Usage

General Description

The chemical compound "(4,5-dihydro-thiazol-2-yl)-[2-(4-methoxy-phenyl)-ethyl]-amine" is a thiazole derivative with an amine functional group and a substituted phenethyl moiety. It is a heterocyclic compound with a five-membered ring containing both sulfur and nitrogen atoms. The presence of the thiazole ring and the amine group makes it a potential candidate for pharmaceutical applications, particularly in the development of new drugs. Additionally, the presence of the methoxy-substituted phenyl group may contribute to its biological activity and pharmacological properties. (4,5-DIHYDRO-THIAZOL-2-YL)-[2-(4-METHOXY-PHENYL)-ETHYL]-AMINE's unique structure and functional groups make it of interest for further research and potential applications in the pharmaceutical and chemical industries.

InChI:InChI=1/C12H16N2OS/c1-15-11-4-2-10(3-5-11)6-7-13-12-14-8-9-16-12/h2-5H,6-9H2,1H3,(H,13,14)

Upstream product

• 55-81-2 4-Methoxyphenethylamine 
• 17427-37-1 2-(4-methoxyphenyl)ethyl isothiocyanate 
• 141-43-5 ethanolamine 

Relevant articles and documents

Synthesis and Octopaminergic Agonist Activity of 2-(Substituted benzylamino)-2-thiazolines

2-(Substituted benzylamino)-2-thiazolines (SBAT) were synthesized by a hydrochloric acid-catalyzed cyclization of the corresponding thioureas, using a reaction of 2-methylthio-2-thiazoline with substituted benzylamines or by alkylating 2-amino-2-thiazoline. 2-(Alkylthio)-2-thiazolines were obtained by alkylating 2-mercaptothiazoline.Most of the SBAT compounds activated adenylate cyclase in homogenates of cockroach ventral nerve cords; the effect of introducing substituents at the phenyl of the SBAT compounds on octopaminergic agonist activity was not significant. 2--2-thiazolines and 2-(alkylthio)-2-thiazolines were not significant octopaminergic agonists.Washing removed nearly all of the activity of one of the SBAT compounds, suggesting that the SBAT compounds bound reversibly to the octopaminergic receptor.