143544-33-6

Upstream product

• 137238-59-6 5-Hydroxy-6-morpholin-4-yl-hexanoic acid benzyl ester 
• 143614-69-1 (R)-5-Hydroxy-6-morpholin-4-yl-hexanoic acid benzyl ester 
• 137238-62-1 (4S,5R)-4-Cyclohexylmethyl-2,2-dimethyl-oxazolidine-3,5-dicarboxylic acid 3-tert-butyl ester 5-((R)-4-carboxy-1-morpholin-4-ylmethyl-butyl) ester 
• 147505-11-1 (1R)-1-(4-morpholinomethyl)-5-oxo-5-(phenylmethoxy)pentyl (4S,5R)-4-(cyclohexylmethyl)-2,2-dimethyl-3-<(1,1-dimethylethoxy)carbonyl>-5-oxazolidinecarbxylate 
• 143614-44-2 (2R,9S,12S,13R)-12-(cyclohexylmethyl)-13-hydroxy-2-(4-morpholinomethyl)-9-<<(phenylmethoxy)carbonyl>amino>-6,10,14-trioxo-1,5-dioxa-11-azacyclotetradecane 
• 137238-61-0 O^ω-<5-<<<(4S,5R)-4-(cyclohexylmethyl)-3-<(1,1-dimethylethoxy)carbonyl>-2,2-dimethyl-5-oxazolidinyl>carbonyl>oxy>-5(R)-(4-morpholinomethyl)pentanoyl>-N^α-<(phenylmethoxy)carbonyl>-L-serine, 1,1-dimethylethyl ester 
• 143508-36-5 (1R)-1-(4-morpholinomethyl)-5-oxo-5-(phenylmethoxy)pentyl (2R,3S)-4-cyclohexyl-2-hydroxy-3-<<(2S)-2-<<(1,1-dimethylethoxy)carbonyl>amino>-3-(phenylmethoxy)propanoyl>amino>butanoate 
• 137238-65-4 (R)-5-[(2R,3S)-3-((S)-2-tert-Butoxycarbonylamino-3-hydroxy-propionylamino)-4-cyclohexyl-2-hydroxy-butyryloxy]-6-morpholin-4-yl-hexanoic acid 
• 143616-04-0 (2R,9S,12S,13R)-12-(cyclohexylmethyl)-9-<<(1,1-dimethylethoxy)carbonyl>amino>-13-hydroxy-2-(4-morpholinomethyl)-6,10,14-trioxo-1,5-dioxa-11-azacyclotetradecane 
• 137238-88-1 4-Oxiranyl-butyric acid benzyl ester 
• 128182-71-8 N-<<2-<(tert-butylacetyl)amino>ethoxy>carbonyl>-Phe 
• 137238-51-8 (3R,4S,7S,14R)-7-Amino-4-cyclohexylmethyl-3-hydroxy-14-morpholin-4-ylmethyl-1,9-dioxa-5-aza-cyclotetradecane-2,6,10-trione 

Relevant academic research and scientific papers

Highly Potent, Orally Active Diester Macrocyclic Human Renin Inhibitors

Replacing one amide bond in macrocyclic renin inhibitors of the general structure 1 and 2 with an ester linkage gave glutamate-derived inhibitors 3 and serine-derived inhibitors 4.While this oxygen-for-nitrogen exchange had little effect on potency in the