1435518-12-9

Upstream product

• 873-77-8 (4-chlorphenyl)magnesium bromide 
• 3350-92-3 5-phenylpent-4-ynoic acid 
• 536-74-3 phenylacetylene 
• 591-50-4 iodobenzene 
• 16031-54-2 1-(4-chlorophenyl)cyclopropan-1-ol 
• 30780-51-9 5-phenylpent-4-ynoic acid methyl ester 

Downstream Products

• 1435518-56-1 3-(4-chlorophenyl)-7-phenylhepta-1,6-diyn-3-yl benzoate 
• 1435517-90-0 3-(4-chlorophenyl)-2,4a-dihydro-1H-fluoren-4-yl benzoate 
• 1435518-31-2 3-(4-chlorophenyl)-7-phenyl-1-(trimethylsilyl)hepta-1,6-diyn-3-ol 
• 1590431-46-1 1-chloro-4-(1-cyclopropylidene-5-phenylpent-4-yn-1-yl)benzene 
• 1590431-56-3 6-(4-chlorophenyl)-2-phenylbicyclo[4.2.0]octa-1,3-diene 

Relevant academic research and scientific papers

Silver-Promoted Oxidative Ring Opening/Alkynylation of Cyclopropanols: Facile Synthesis of 4-Yn-1-ones

A new silver-promoted oxidative ring opening/alkynylation of cyclopropanols with ethynylbenziodoxolones (EBX) is described. This method enables the formation of alkylated alkynes via a sequence of ring opening and alkynylation. Control experiments support

K2CO3-Mediated Cyclization and Rearrangement of γ,δ-Alkynyl Oximes to Form Pyridols

A novel K2CO3-mediated cyclization and rearrangement of γ,δ-alkynyl oximes for the synthesis of pyridols is described. The process accomplishes an efficient [1,3] rearrangement of the O-vinyl oxime intermediate which is in situ generated from the intramolecular nucleophilic addition of γ,δ-alkynyl oximes. The reaction employs readily accessible starting materials, tolerates a wide range of functional groups, and gives a variety of synthetically challenging pyridols in good yields.

Gold-catalyzed enantioselective ring-expanding cycloisomerization of cyclopropylidene bearing 1,5-enynes

An enantioselective ring-expanding cycloisomerization of 1,5-enynes bearing a cyclopropylidene moiety has been developed. This methodology provides a new approach to bicyclo[4.2.0]octanes, a structural motif present in many biologically active natural products.

Gold-catalyzed cycloisomerization of 1,6-diyne carbonates and esters to 2,4a-dihydro-1 H-fluorenes

A synthetic method to prepare 2,4a-dihydro-1H-fluorenes efficiently from gold(I)-catalyzed 1,2-acyloxy migration/cyclopropenation/Nazarov cyclization of 1,6-diyne carbonates and esters is described. The suggested reaction pathway provides rare examples of [2,3]-sigmatropic rearrangement in this class of compounds as well as the involvement of an in situ formed cyclopropene intermediate in gold catalysis. Experimental and ONIOM(QM:QM′) [our own n-layered integrated molecular orbital and molecular mechanics(quantum mechanics:quantum mechanics′)] computational studies based on the proposed Au carbenoid species provide insight into this unique selectivity.