143565-21-3Relevant academic research and scientific papers
A novel one-pot method for the stereoselective synthesis of tetrahydropyrimidinones in a low melting mixture
Baskaran, Sundarababu,Devi, Pramila,Lambu, Mallikharjuna Rao
, p. 4164 - 4168 (2020)
A direct and metal free one-pot method has been developed for the stereoselective synthesis of tetrahydropyrimidinone derivatives from a vinyl arene and formaldehyde using a tartaric acid-dimethylurea (TA : DMU) melt as a green reaction medium. The substrate scope of this method is very general and the tetrahydropyrimidinone (THPM) derivatives are synthesized in good yields with a high degree of diastereoselectivity. In this reaction, the melt plays a triple role as the solvent, catalyst and reagent.
