143577-41-7

Upstream product

• 1125-88-8 benzaldehyde dimethyl acetal 
• 143424-94-6 dimethyl 4-t-butyldimethylsiloxy-N-methoxycarbonyl-1,2,3,6-tetrahydropyridine-2,2-carboxylate 

Downstream Products

• 143425-02-9 dimethyl (E)-5-benzylidene-N-methoxycarbonyl-4-oxo-piperidine-2,2-dicarboxylate 
• 143577-37-1 (trans)-5-benzyl-4-oxo-piperidine-2-carboxylic acid hydrobromide 
• 143577-38-2 (2,4-cis/2,5-trans)-5-benzyl-4-hydroxy-piperidine-2-carboxylic acid hydrochloride 
• 143425-03-0 dimethyl 5-benzyl-N-methoxycarbonyl-4-oxo-piperidine-2,2-dicarboxylate 
• 143425-04-1 benzyl 4-syn-4-benzyl-7-oxo-6-oxa-2-azabicyclo<3.2.1>octane-2-carboxylate 

Relevant academic research and scientific papers

Amino acids, XII: (±)Pipecolic acid derivatives - Part 2: An expedient synthetic entry to substituted pipecolic acids

The Diels-Alder product 1 is transformed by Noyori reaction and catalytic hydrogenation to 4. Hydrolysis with concomitant decarboxylation of 4 furnishes the trans configuration amino acid 5. Functional group transformation (reduction, lactonization) of 5