143577-48-4Relevant academic research and scientific papers
Alkylation of the cyclic sulfamate of prolinol. Preparation of optically active 2-alkyl-substituted pyrrolidines
Cooper,McCarthy,Martin
, p. 5895 - 5896 (2007/10/02)
Treatment of the cyclic sulfamate of (R)-prolinol (1) with aromatic lithium reagents, followed by acidic hydrolysis, gives 2-substituted pyrrolidines 3a-c in moderate yields.
Process for preparing cyclic amines and intermediate products thereof
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, (2008/06/13)
A process for preparing a cyclic amine of Formula I STR1 in which R1 is phenyl, optionally substituted by 1 to 3 lower alkoxy groups; R2, R3 and R4 are independently hydrogen or lower alkyl; and n is 1 or 2, comprises (1) converting an aminoalcohol of Formula III STR2 to a dioxooxathiazolidine of Formula II STR3 in which R2, R3, R4 and n are as defined above; and (2) reacting the dioxooxathiazolidine of Formula II with an organometallic nucleophile, R1 M*, wherein R1 is as defined above, and hydrolyzing the resulting sulfamate salt.
