1435806-75-9Relevant academic research and scientific papers
INHIBITORS OF RECEPTOR INTERACTING PROTEIN KINASE I FOR THE TREATMENT OF DISEASE
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Paragraph 0436-0437, (2021/03/13)
Disclosed herein are compounds which inhibit RIPK1, pharmaceutical compositions, and methods of treatment of RIPK1 -mediated diseases, such as neurodegenerative disorders, inflammatory disorders, and cancer.
INHIBITORS OF CGAS FOR TREATING AUTOINFLAMMATORY DISEASES AND CANCER METASTASIS
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Paragraph 0216, (2020/09/30)
Tri-cyclyl nitrogen-containing heterocyclic compounds are disclosed. The compounds are inhibitors of human cGAS in interferon-producing cell types. They are thus useful as therapeutic agents for treating cGAS-related autoimmune diseases in humans.
Preparation method of 3,5-dichloro-4-fluorobromobenzene compound
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Paragraph 0036-0040, (2020/12/14)
The invention relates to a preparation method of 3,5-dichloro-4-fluorobromobenzene. According to the preparation method, 2-fluoro-3-chloronitrobenzene is used as a starting raw material and subjectedto bromination, reduction and diazochlorination to synthesize 3,5-dichloro-4-fluorobromobenzene. The whole synthesis route of the method has the advantages of accessible raw materials, mild reaction conditions, environment friendliness, low equipment requirements and high product purity and yield.
Indole compound as well as preparation method, pharmaceutical composition and application thereof
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Paragraph 0681-0686, (2019/12/02)
The invention discloses an indole compound as well as a preparation method, a pharmaceutical composition and an application thereof. Specifically, the invention relates to an indole derivative as shown in a general formula I and a medicinal salt thereof, a preparation method of the indole derivative, a composition containing one or more compounds, and applications of the compounds in preparation of medicines for preventing and/or treating diseases related to IDO1 and/or TDO.
2,3,4,5-TETRAHYDRO-1H-PYRIDO[4, 3-B]INDOLE INHIBITORS OF CGAS FOR TREATING AUTOINFLAMMATORY DISEASES
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Paragraph 0108, (2019/08/26)
1-(3,4-Dihydro-1H-pyrido[4, 3-b]indol-2(5H)-yl)-2-hydroxyethanones are disclosed. The compounds are inhibitors of human cGAS in interferon-producing cell types. They are thus useful as therapeutic agents for treating cGAS-related autoimmune diseases in humans.
BENZIMIDAZOLES FOR USE IN THE TREATMENT OF CANCER AND INFLAMMATORY DISEASES
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Paragraph 00494, (2017/04/11)
Provided herein are methods for treating, preventing, or ameliorating one or more symptoms of a condition, disorder, or disease mediated by a lipid kinase or a protein kinase with benzimidazoles, for example, of Formula I or II, and pharmaceutical compositions thereof. Also provided herein are benzimidazoles, and pharmaceutical compositions thereof; and methods of their use for treating, preventing, or ameliorating one or more symptoms of a proliferative disease.
