143589-83-7

Upstream product

• 7439-93-2 lithium 
• 143589-82-6 1(R,S)-(p-tert-butoxyphenyl)ethylamine 

Downstream Products

• 150494-43-2 1-(tert-butoxy)-4-<1(R,S)-(phthalylamino)-1-ethyl>-1,4-cyclohexadiene 

Relevant academic research and scientific papers

HIV PROTEASE INHIBITORS

Peptide mimics, having a constrained peptide backbone conformation, are HIV protease inhibitors. A compound of this invention is, for example, 3-Benzyl-5(alaninyl-1-aminoethyl)-2,3,6,7-tetrahydro-N-azepinyl-2-propionyl-valinyl-valinyl methyl ester.

A novel constrained reduced-amide inhibitor of HIV-1 protease derived from the sequential incorporation of γ-turn mimetics into a model substrate

C7 mimetics, designed to lock three amino acid residues of a peptide chain into a γ-turn conformation, were introduced sequentially between the P3 to P2' positions of a model HIV-1 protease substrate I (resulting in compou