143591-61-1

Basic information

• Product Name: 3-BROMO-8-CHLOROIMIDAZO[1,2-A]PYRAZINE
• Synonyms: 3-BROMO-8-CHLOROIMIDAZO[1,2-A]PYRAZINE;8-Chloro-3-bromoimidazo[1,2-a]pyrazine;Imidazo[1,2-a]pyrazine, 3-bromo-8-chloro-
• CAS NO: 143591-61-1
• Molecular Formula: C₆H₃BrClN₃
• Molecular Weight: 232.47
• Mol File: 143591-61-1.mol
• Article Data: 19

Chemical Properties

• Appearance: /
• Density: 2.038 g/cm³
• Refractive Index: 1.768
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: -1.45±0.30(Predicted)
• CAS DataBase Reference: 3-BROMO-8-CHLOROIMIDAZO[1,2-A]PYRAZINE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-BROMO-8-CHLOROIMIDAZO[1,2-A]PYRAZINE(143591-61-1)
• EPA Substance Registry System: 3-BROMO-8-CHLOROIMIDAZO[1,2-A]PYRAZINE(143591-61-1)

Safety Data

• Hazardous Substances Data: 143591-61-1(Hazardous Substances Data)

Usage

Physical Form

Solid

InChI:InChI=1/C6H3BrClN3/c7-4-3-10-6-5(8)9-1-2-11(4)6/h1-3H

Upstream product

• 69214-33-1 8-chloroimidazo[1,2-α]pyrazine 
• 937790-53-9 BrH*C₆H₄ClN₃ 

Downstream Products

• 918545-19-4 5'-(8-chloro-imidazo[1,2-a]pyrazin-3-yl)-2'-fluoro-biphenyl-2-carbonitrile 
• 918545-20-7 5'-(8-chloro-imidazo[1,2-a]pyrazin-3-yl)-4,2'-difluoro-biphenyl-2-carbonitrile 
• 918545-22-9 5'-(8-chloro-imidazo[1,2-a]pyrazin-3-yl)-6,2'-difluoro-biphenyl-2-carbonitrile 
• 689297-65-2 2'-fluoro-5'-(8-oxo-7,8-dihydroimidazo[1,2-a]pyrazin-3-yl)-biphenyl-2-carbonitrile 
• 689297-63-0 2'-fluoro-5'-(8-methoxyimidazo[1,2-a]pyrazin-3-yl)-biphenyl-2-carbonitrile 
• 918545-23-0 4,2'-difluoro-5'-(8-methoxy-imidazo[1,2-a]pyrazin-3-yl)-biphenyl-2-carbonitrile 
• 689297-98-1 4,2'-difluoro-5'-(8-oxo-7,8-dihydroimidazo[1,2-a]pyrazin-3-yl)-biphenyl-2-carbonitrile 
• 918544-48-6 6,2'-difluoro-5'-(8-oxo-7,8-dihydro-imidazo[1,2-a]pyrazin-3-yl)-biphenyl-2-carbonitrile 
• 918545-44-5 6,2'-difluoro-5'-(8-methoxy-imidazo[1,2-a]pyrazin-3-yl)-biphenyl-2-carbonitrile 
• 1231257-91-2 3-bromo-N-cyclohexylimidazo[1,2-a]pyrazin-8-amine 
• 1231257-93-4 3-bromo-8-(3-(trifluoromethyl)phenoxy)imidazo[1,2-a]pyrazine 
• 887475-39-0 3-bromo-8-methylsulfanyl-imidazo[1,2-a]pyrazine 
• 1231257-89-8 3-bromo-8-((3-(trifluoromethyl)phenyl)amino)imidazo[1,2-a]pyrazine 
• 1236354-30-5 3-bromo-N-(2-fluoro-4-(methylsulfonyl)phenyl)imidazo[1,2-a]pyrazin-8-amine 

Relevant articles and documents

SUBSTITUTED FUSED AROMATIC RING DERIVATIVE, COMPOSITION AND USE THEREOF

Provided are a substituted fused aromatic ring derivative, a composition containing the compound, and a use thereof. The substituted fused aromatic ring derivative is a compound represented by formula (I) or a tautomer, stereoisomer, prodrug, crystal form, pharmaceutically acceptable salt, hydrate or solvate thereof. The compound and the composition can be used to treat various protein tyrosine kinase-mediated diseases or disorders.

COMPOUND USED AS AUTOPHAGY REGULATOR, AND PREPARATION METHOD THEREFOR AND USES THEREOF

It is related to compounds used as autophagy modulators and a method for preparing and using the same, specifically providing a compound of general formula (I), or pharmaceutically acceptable salts thereof, which is a type of autophagy modulators, particularly mammalian ATG8 homologues modulators.

Design and synthesis of new imidazo[1,2-a]pyridine and imidazo[1,2-a]pyrazine derivatives with antiproliferative activity against melanoma cells

Melanoma is an aggressive form of skin cancer and it is generally associated with poor prognosis in patients with late-stage disease. Due to the increasing occurrence of melanoma, there is a need for the development of novel therapies. A new series of diarylamide and diarylurea derivatives containing imidazo[1,2-a]pyridine or imidazo[1,2-a]pyrazine scaffold was designed and synthesized to investigate their in vitro efficacy against the A375P human melanoma cell line. We found several compounds expressing submicromolar IC50 values against the A375P cells, from which 15d, 17e, 18c, 18h, 18i demonstrated the highest potencies with IC50 below 0.06 μM.