1435939-75-5

Upstream product

• 123-08-0 4-hydroxy-benzaldehyde 
• 17356-08-0 thiourea 
• 109-77-3 malononitrile 

Relevant academic research and scientific papers

Synthesis and evaluation of cytotoxicity of 6-amino-4-aryl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carbonitriles

Several derivatives of 6-amino-4-aryl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carbonitriles were synthesized via Biginelli type reaction and tested for their anti-proliferative activity on human breast cancer (MCF-7) and human colon carcinoma (HT29) cell

An efficient one-pot synthesis of new 2- Thioxo and 2-oxo-pyrimidine-5- carbonitriles in ball-milling under solvent-free and catalyst-free conditions

Various 2-thioxo and 2-oxo-1,2,3,4-tetrahydro-pyrimidine-5-carbonitriles were synthesized in very high yields in 40 min through a direct condensation of an equimolar amount of an aldehyde, malononitrile, and thiourea/urea under ball mill solvent-free and catalyst-free conditions.