1435972-51-2Relevant academic research and scientific papers
Preparation of S14161 and its analogues and the discovery of 6-bromo-8-ethoxy-3-nitro-2H-chromene as a more potent antitumor agent in vitro
Yin, Shu-Qiang,Shi, Min,Kong, Ting-Ting,Zhang, Cheng-Mei,Han, Kunkun,Cao, Biyin,Zhang, Zubin,Du, Xiaolin,Tang, Long-Qian,Mao, Xinliang,Liu, Zhao-Peng
, p. 3314 - 3319 (2013)
The small chemical compound 8-ethoxy-2-(4-fluorophenyl)-3-nitro-2H-chromene (S14161) was recently identified as an inhibitor of the phosphoinositide 3-kinase (PI3K). In the present study, we designed a novel synthesis of S14161 and prepared a series of its analogues via the oxa-Michael-Henry reaction in the presence of catalytic amounts of l-proline and triethylamine. Further structural simplification led to the identification of 6-bromo-8-ethoxy-3-nitro- 2H-chromene (BENC-511) that exhibited potent antiproliferative activities against a panel of 12 tumor cell lines. Compared with S14161, BENC-511 was more potent in blocking the AKT phosphorylation and inducing cancer cell apoptosis. BENC-511 also displayed more potent effects on human umbilical vein epithelial cells (HUVEC) migration, suggesting its anti-angiogenesis activity.
Microwave-assisted One-pot, Three-component Regiospecific and Sterospecific Synthesis of Spiro Indanone Pyrrolidine/Piperidine Fused Nitrochromene Derivatives Through 1,3-Dipolar Cycloaddition Reactions
Nayak, Sabita,Panda, Pravati,Mohapatra, Seetaram,Raiguru, Bishnuprasad,Baral, Nilofar
, p. 1757 - 1770 (2019/04/26)
A simple, straightforward, and versatile protocol for the synthesis of spiro indanone pyrrolidine/piperidine fused nitrochromene derivatives is described. The synthesis of a new series of spirocyclic molecules has been expediently accomplished via a one-p
Microwave-assisted rapid and efficient synthesis of chromene-fused pyrrole derivatives through multicomponent reaction and evaluation of antibacterial activity with molecular docking investigation
Baral, Nilofar,Kumar, P. Sudhir,Mishra, Deepak Ranjan,Mishra, Nilima Priyadarsini,Mohapatra, Seetaram,Nayak, Mukesh,Nayak, Sabita,Panda, Pravati,Raiguru, Bishnu Prasad
, (2020/01/03)
The current study aimed to identify a new strategy of FeCl3 catalyzed multicomponent synthesis of substituted 2H-chromene–fused pyrrole derivatives. A series of chromene-based pyrrole prepared by employing an array of 3-nitro-2H-chromenes, anil
