143603-49-0

Basic information

• Product Name: Piperidine, 1-[1-(5-nitrobenzo[b]thien-2-yl)cyclohexyl]-
• CAS NO: 143603-49-0
• Molecular Formula: C19H24N2O2S
• Molecular Weight: 344.478
• Mol File: 143603-49-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Piperidine, 1-[1-(5-nitrobenzo[b]thien-2-yl)cyclohexyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Piperidine, 1-[1-(5-nitrobenzo[b]thien-2-yl)cyclohexyl]-(143603-49-0)
• EPA Substance Registry System: Piperidine, 1-[1-(5-nitrobenzo[b]thien-2-yl)cyclohexyl]-(143603-49-0)

Safety Data

• Hazardous Substances Data: 143603-49-0(Hazardous Substances Data)

Upstream product

• 95-15-8 Benzo[b]thiophene 
• 143603-26-3 1-(2-benzothiophenyl)cyclohexylamine 
• 108-94-1 cyclohexanone 
• 6774-43-2 1-(benzo[b]thiophen-2-yl)cyclohexan-1-ol 
• 111-24-0 1,5-dibromo-pentane 
• 143603-25-2 2-(1-Azido-cyclohexyl)-benzo[b]thiophene 

Downstream Products

• 143603-23-0 1-<1-(5-isothiocyanato-2-benzothienyl)cyclohexyl>piperidine 
• 143603-52-5 1-<1-(5-amino-2-benzothienyl)cyclohexyl>piperidine 

Relevant articles and documents

Synthesis of Isothiocyanato-1-thienyl)cyclohexyl>piperidines, Potential Irreversible Ligands at the Dopamine Re-uptake Site

Isomeric isothiocyanate derivatives 2-7 of the potent dopamine re-uptake (DA) inhibitor 1-thienyl)cyclohexyl>piperidine (BTCP 1) have been synthesized as potential irreversible ligands for this site.NaNO2-CF3CO2H provided a mild procedure for mononitration of the benzothienyl ring of 1 as a route to aryl isothiocyanates 5-7.Novel methodology, utilizing 3,3-ethylenedioxypentane-1,5-diol dimethanesulfonate ester is described for the synthesis of piperidone 13, a precursor for 4-isothiocyanatopiperidine 2.NaBH4 or LiAlH4 reduction of 4-(2-benzothienyl)-4-hydroxycyclohexanone 18 and 4-(2-benzothienyl)-4-(piperidino)cyclohexanone oxime 35 gives the corresponding cis-diol 21 and cis-cyclohexane-1,4-diamine 36 as the major isomers which have been investigated as precursors to the cyclohexane ring isothiocyanates 3 and 4.Alternative routes to 3 and 4 are compared and their stereochemical outcome investigated.