143612-13-9Relevant academic research and scientific papers
Imidazole-catalyzed three-component cascade reaction for the facile synthesis of highly substituted 3,4-dihydropyridin-2-one derivatives
Liu, Zhiqiang,Tan, Lu,Wu, Qi,Lin, Xianfu
, p. 2343 - 2348,6 (2012/12/12)
A novel one-pot protocol for the synthesis of valuable 3,4-dihydropyridin- 2-ones from the condensation of aldehyde with cyanoacetamide and 1,3-dicarbonyl compounds in the presence of imidazole was developed. A series of aldehydes and 1,3-dicarbonyl compounds were employed to examine the scope of substrates for this protocol. This reaction proceeded through the formation of one ring and four new bonds (two Ci￡C, one Ci￡N, one Ci￡C) via the sequence involving Knoevenagel condensation, Michael addition and intramolecular cyclization with moderate to excellent yields. All new compounds were characterized by IR, 1H NMR, 13C NMR and HRMS. Copyright
