143619-30-1

Basic information

• Product Name: (S)-2-Cyano-5-(2-methoxy-phenyl)-2-methyl-5-oxo-pentanoic acid isopropyl ester
• Synonyms: (S)-2-Cyano-5-(2-methoxy-phenyl)-2-methyl-5-oxo-pentanoic acid isopropyl ester
• CAS NO: 143619-30-1
• Molecular Weight: 303.358
• Mol File: 143619-30-1.mol

Chemical Properties

• CAS DataBase Reference: (S)-2-Cyano-5-(2-methoxy-phenyl)-2-methyl-5-oxo-pentanoic acid isopropyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-2-Cyano-5-(2-methoxy-phenyl)-2-methyl-5-oxo-pentanoic acid isopropyl ester(143619-30-1)
• EPA Substance Registry System: (S)-2-Cyano-5-(2-methoxy-phenyl)-2-methyl-5-oxo-pentanoic acid isopropyl ester(143619-30-1)

Safety Data

• Hazardous Substances Data: 143619-30-1(Hazardous Substances Data)

Upstream product

• 143619-32-3 (R)-isopropyl 2-cyano-2-methyl-5-oxopentanoate 
• 16750-63-3 2-methoxyphenylmagnesium bromide 
• 30378-24-6 isopropyl 2-cyanopropanoate 
• 77942-10-0 1-(2-methoxyphenyl)prop-2-en-1-one 

Relevant articles and documents

Asymmetric Michael reaction of α-cyano carboxylates catalyzed by a rhodium complex with trans-chelating chiral diphosphine PhTRAP

Asymmetric Michael reaction of 2-cyanopropionates with vinyl ketones or acrolein in the presence of 0.1-1 mol% of a rhodium catalyst prepared in situ from RhH(CO)(PPh3)3 and a trans-chelating chiral diphosphine ligand (S,S)- (R,R)-PhTRAP in benzene at 3-5 °C gave optically active Michael adducts with high enantiomeric excesses (83-93% ee) in high yields. The reaction of 2- cyanopropionate with methacrolein and crotonaldehyde proceeded somewhat slowly, giving diastereomer mixtures in moderate enantioselectivities but in low diastereoselectivities. The reaction of 2-cyanobutyrate and 2-cyano-3- methylbutyrate with acrolein gave corresponding Michael adducts with much lower enantiomeric excesses than that of 2-cyanopropionates. The Michael addition product from acrolein was converted into an optically active α- methyl-α-amino acid.