1436402-36-6

Basic information

• Product Name: C₃₄H₂₉NO₇
• Synonyms: C₃₄H₂₉NO₇
• CAS NO: 1436402-36-6
• Molecular Weight: 563.607
• Mol File: 1436402-36-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₃₄H₂₉NO₇(CAS DataBase Reference)
• NIST Chemistry Reference: C₃₄H₂₉NO₇(1436402-36-6)
• EPA Substance Registry System: C₃₄H₂₉NO₇(1436402-36-6)

Safety Data

• Hazardous Substances Data: 1436402-36-6(Hazardous Substances Data)

Upstream product

• 3240-94-6 N-(2-chlorethyl)morpholine 
• 1105056-24-3 9-hydroxy-6-(4-hydroxyphenyl)-2,2-diphenyl-8H-1,3-dioxolo[4,5-g][1]benzopyran-8-one 

Downstream Products

• 529-53-3 scutellarein 

Relevant articles and documents

Efficient chemical synthesis of a scutellarein derivative containing morpholine ring

Scutellarin (1) [5,6-dihydroxy-2-(4-hydroxyphenyl)-4-oxo-4H-1-benzopyran-7- yl β-D-glucopyranosiduronic acid] is very effective in the clinical treatment of cerebral infarction and coronary heart disease in China. Pharmacokinetic studies showed that scutellarin (1) is readily metabolized to scutellarein (2) [5,6,7-trihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one] in the intestine by β-glucuronide enzyme prior to absorption. In order to improve the biological activity of scutellarin (1), our group has previously synthesized many scutellarin derivatives based on their in vivo metabolic mechanism. The results showed that morpholine ring substituted at C-7 or C-8 position induced better antioxidant activity, water solubility and anticoagulant activity compared to scutellarin (1). In this paper, an efficient synthetic method for the construction of 5,6,7-trihydroxy-2-[4-[2-(4-morpholinyl)ethoxy] phenyl]-4H-1-benzopyran-4-one (5) is reported. This synthetic route will facilitate the synthesis of scutellarein derivatives containing an amine side chain at the C-4′ position.