1436419-12-3Relevant articles and documents
Detour of prenostodione synthesis towards pyrazolones for antibacterial activity
Rasapalli, Sivappa,Fan, Yingjun,Yu, Menglong,Rees, Christiaan,Harris, John T.,Golen, James A.,Jasinski, Jerry P.,Rheingold, Arnold L.,Kwasny, Steven M.,Opperman, Timothy J.
, p. 3235 - 3238 (2013/06/27)
Our attempts to prepare indolyl acid (3), enroute to prenostodione (2), from phenyl-hydrazine following a reported procedure of Fischer-Indole synthesis rather lead to ethyl 2-(5-oxo-1-phenyl-2,5-dihydro-1H-pyrazol-3-yl)acetate as a major product, which underwent facile condensation with aldehydes to provide the pyrazolones. Intrigued by the opportunity for the diversity oriented synthesis of substituted pyrazolones, we have developed a facile one pot approach for pyrazolones and screened for antibacterial activity and, herein, results are reported.