143643-00-9

Upstream product

• 143642-98-2 Dithiocarbonic acid O-[(1S,2S,3R,5R)-5-benzyloxymethyl-3-(tert-butyl-diphenyl-silanyloxy)-2-methylsulfanylthiocarboxyoxy-cyclopentyl] ester S-methyl ester 
• 143642-96-0 ((3aS,4R,6R,6aS)-6-Benzyloxymethyl-2,2-dimethyl-tetrahydro-cyclopenta[1,3]dioxol-4-yloxy)-tert-butyl-diphenyl-silane 
• 143642-97-1 (1S,2S,3R,5R)-3-Benzyloxymethyl-5-(tert-butyl-diphenyl-silanyloxy)-cyclopentane-1,2-diol 
• 143642-94-8 (3aR,6S,6aR)-6-Benzyloxymethyl-2,2-dimethyl-tetrahydro-cyclopenta[1,3]dioxol-4-one 
• 143642-95-9 (3aS,4S,6S,6aR)-6-Benzyloxymethyl-2,2-dimethyl-tetrahydro-cyclopenta[1,3]dioxol-4-ol 
• 89291-75-8 (3aR*,6aR*)-6-Benzyloxymethyl-2,2-dimethyl-4,6a-dihydro-3aH-cyclopenta[d][1,3]dioxol-4-one 
• 143643-01-0 (R)-4-Benzyloxymethyl-cyclopent-2-enone 
• 143642-99-3 ((1S,4R)-4-Benzyloxymethyl-cyclopent-2-enyloxy)-tert-butyl-diphenyl-silane 

Downstream Products

• 143643-08-7 Benzoic acid (1S,2S)-4-(2-amino-6-benzyloxy-purin-9-yl)-2-benzyloxymethyl-cyclopentylmethyl ester 
• 143643-06-5 Benzoic acid (1S,2S)-2-benzyloxymethyl-4-(6-chloro-purin-9-yl)-cyclopentylmethyl ester 
• 143643-10-1 Benzoic acid (1R,2R,4R)-2-benzyloxymethyl-4-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-cyclopentylmethyl ester 
• 143643-09-8 Benzoic acid (1R,2R,4R)-4-(4-amino-2-oxo-2H-pyrimidin-1-yl)-2-benzyloxymethyl-cyclopentylmethyl ester 
• 143643-05-4 Benzoic acid (1S,2S)-2-benzyloxymethyl-4-methanesulfonyloxy-cyclopentylmethyl ester 
• 143643-03-2 Benzoic acid (1R,2R)-2-benzyloxymethyl-4-oxo-cyclopentylmethyl ester 
• 143643-07-6 Benzoic acid (1R,2R)-4-amino-2-benzyloxymethyl-cyclopentylmethyl ester 
• 143643-04-3 Benzoic acid (1R,2R)-2-benzyloxymethyl-4-hydroxy-cyclopentylmethyl ester 
• 143643-02-1 (3R,4R)-3-Benzyloxymethyl-4-hydroxymethyl-cyclopentanone 
• 118237-82-4 (+/-)-cis-9H-9-<4-(hydroxymethyl)-2-cyclopenten-1-yl>adenine 
• 72346-00-0 (+/-)-9-<2α,3α-dihydroxy-4α-(hydroxymethyl)cyclopent-1α-yl>adenine 
• 143643-01-0 (R)-4-Benzyloxymethyl-cyclopent-2-enone 

Relevant academic research and scientific papers

A Novel, One-Pot Ring Expansion of Cyclobutanones. Syntheses of Carbovir and Aristeromycin

A novel, one-pot ring-expansion procedure was developed using Me3S(O)I, NaH, and Sc(OTf)3. The scope and limitations were briefly examined, and a tentative mechanism was proposed. Application of the methodology to known cyclobutanone 1 provided the corresponding cyclopentanone, which was successfully advanced to (+)-carbovir and (+)-aristeromycin.

Carbocyclic ring-enlarged oxetanocin analogues

Carbocyclic versions of 2′,3′-dideoxy-3′C-hydroxymethyl nucleosides with adenine, guanine, uracil and cytosine bases were synthesized from a common cyclopentenone precursor. The extra hydroxymethyl moiety was introduced by photochemical addition of methan